2-Tert-butyl-5-methylphenol;2-methyl-5-propan-2-ylphenol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-Tert-butyl-5-methylphenol;2-methyl-5-propan-2-ylphenol
• 英文别名: 2-tert-butyl-5-methylphenol;2-methyl-5-propan-2-ylphenol
• 化学式: C21H30O2
• 分子量: 314.5
• InChiKey: NLCLMGFLZVEINY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.82
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHODS OF TREATMENT OF KERATINOCYTE-DERIVED LESIONS
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP2919773A1

  公开（公告）日：2015-09-23
• [EN] METHODS OF TREATMENT OF KERATINOCYTE-DERIVED LESIONS<br/>[FR] MÉTHODES DE TRAITEMENT DE LÉSIONS ISSUES DE KÉRATINOCYTES
  申请人：UNIV COLUMBIA

  公开号：WO2014078868A1

  公开（公告）日：2014-05-22

  TRPV3 agonists, e.g., camphor, camphor-oil which contain monoterpene constitutents, 2-APB and derivatives thereof arrest human keratinocyte proliferation and promote differentiation. Methods are provided for diagnosing and treating or preventing keratinocyte-derived lesions, e.g., SCC, (including high-risk forms), non-melanoma skin cancers (including high-risk forms), and actinic keratinosis ("AK") by administering to an afflicted subject a therapeutically effective amount of one or more TRPV3 agonists or derivatives thereof. Pharmaceutical compositions that contain therapeutically effective amounts of one or more TRPV3 agonists or derivatives thereof are also contemplated.