5-甲基-2-(异丙基)环己基烟酸酯 | 40594-65-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 5-甲基-2-(异丙基)环己基烟酸酯
• 英文名称: Menthylnicotinat
• 英文别名: nicotinic acid menthyl ester；Nicotinsaeure-menthylester；5-Methyl-2-(isopropyl)cyclohexyl nicotinate；(5-methyl-2-propan-2-ylcyclohexyl) pyridine-3-carboxylate
• CAS: 40594-65-8
• 化学式: C₁₆H₂₃NO₂
• 分子量: 261.364
• InChiKey: GGOHHUHCISYDOX-UHFFFAOYSA-N

物化性质

• 沸点：
  292.23℃[at 101 325 Pa]
• 密度：
  1.031[at 20℃]
• LogP：
  5.09 at 25℃

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  烟酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 三氯氧磷 、 苯 作用下， 生成 5-甲基-2-(异丙基)环己基烟酸酯
  参考文献：
  名称：

  DE440935

  摘要：

  公开号：

文献信息

• Novel topical formulations comprising vesicle delivery systems
  申请人：JOHNSON & JOHNSON CONSUMER PRODUCTS, INC.

  公开号：EP1060732A2

  公开（公告）日：2000-12-20

  This invention relates to a method for enhancing the transmembrane and/or topical penetration of pharmacologically active substances using a certain vesicle delivery system as an enhancing agent, and an optional detergent, as well as the compositions used therein. Various active agents, such as hair growth agents, hair inhibitor agents, anti-acne agents, depilatory agents, anti-aging agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention.

  本发明涉及一种利用某种囊泡递送系统作为增强剂和任选的洗涤剂来增强药理活性物质的跨膜和/或局部渗透的方法，以及其中使用的组合物。使用本发明的组合物，可将各种活性剂，如生发剂、毛发抑制剂、抗痤疮剂、脱毛剂、抗衰老剂和脱色剂有效地输送到皮肤、毛囊和皮脂腺中。
• Compositions and method for the stimulation of the female and male sexual response
  申请人：Multichem S.A.S. di Gabriele Segalla

  公开号：EP2881107A1

  公开（公告）日：2015-06-10

  A description is given of compositions for topical use comprising menthyl nicotinate as primary active ingredient, in such a dose as to stimulate in a subject the sexual response, preferably in such a dose as to maximise this response in a relative short time, and at least one appropriate lipophilic vehicle such as to solubilise the menthyl nicotinate and allow a rapid absorption thereof in the epithelial tissues of the female and/or male erogenous zones.

  本文介绍了外用组合物，其主要活性成分是烟酸薄荷酯，其剂量可刺激受试者的性反应，最好是在相对较短的时间内使这种反应最大化；还包括至少一种适当的亲脂载体，可使烟酸薄荷酯溶解，并能被女性和/或男性性感区的上皮组织迅速吸收。
• Menthyl nicotinate synthesis process
  申请人：MULTICHEM IP LLC

  公开号：US10654806B2

  公开（公告）日：2020-05-19

  Disclosed is a process for preparing menthyl nicotinate with high purity and yield, which consists of a transesterification reaction of menthol with a C1-C4 alkyl ester of the nicotinic acid, in the presence of an alkaline catalyst belonging to the class of C1-C4 alkoxides, linear or branched, and a vacuum distillation of the mixture of reaction products, in the presence of activated carbons.

  本发明公开了一种制备高纯度、高收率烟酸薄荷酯的工艺，该工艺包括薄荷醇与烟酸的 C1-C4 烷基酯在属于 C1-C4 烷氧基（直链或支链）类的碱性催化剂存在下进行酯交换反应，以及在活化碳存在下对反应产物混合物进行真空蒸馏。
• NEW MENTHYL NICOTINATE SYNTHESIS PROCESS
  申请人：Multichem R&D S.R.L.

  公开号：EP3464241B1

  公开（公告）日：2020-06-10
• COMPOSITIONS AND METHOD FOR THE STIMULATION OF THE FEMALE AND MALE SEXUAL RESPONSE
  申请人：SEGALLA Gabriele

  公开号：US20150157615A1

  公开（公告）日：2015-06-11

  Compositions for topical use including menthyl nicotinate as primary active ingredient, in such a dose as to stimulate in a subject the sexual response, preferably in such a dose as to maximize this response in a relative short time, and at least one appropriate lipophilic vehicle so as to solubilize the menthyl nicotinate and allow a rapid absorption thereof in the epithelial tissues of the female and/or male erogenous zones.