(5R)-5-methyl-N-[(3R)-2-oxooxolan-3-yl]-2-propan-2-ylcyclohexane-1-carboxamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5R)-5-methyl-N-[(3R)-2-oxooxolan-3-yl]-2-propan-2-ylcyclohexane-1-carboxamide
• 化学式: C₁₅H₂₅NO₃
• 分子量: 267.36
• InChiKey: CPHSLHFCOXCOJU-IKWCTNDRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Cooling composition
  申请人：FIRMENICH SA

  公开号：US11174249B2

  公开（公告）日：2021-11-16

  Described herein is a composition of matter comprising i) at least one compound of formula (I) in the form of any of its stereoisomers; and wherein R1 represents a phenyl group optionally substituted by one or two C1-3 alkyl or alkoxy groups or by one or two halides group; R2 and R3 represent, independently from each other a heterocyclic group comprising from 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, optionally substituted by one or two C1-3 alkyl groups; and ii) at least a C1-6 linear or branched alkyl lactate. Also described herein is a method of using the composition of matter as part of a flavoring or perfuming composition or of a flavoring or perfuming consumer product. Also described herein is a process to prepare the composition of matter and the polymorph of compound of formula (I).

  本文描述的物质组合物包括 i) 至少一种式（I）化合物 其中 R1 代表苯基，可任选被一个或两个 C1-3 烷基或烷氧基团或一个或两个卤化物基团取代；R2 和 R3 各自代表杂环基团，包含 1 至 3 个选自氮、氧和硫的杂原子，可任选被一个或两个 C1-3 烷基基团取代；以及 至少一个 C1-6 直链或支链烷基乳酸酯。 本文还描述了一种将物质组合物用作调味或加香组合物或调味或加香消费品的一部分的方法。本文还描述了制备物质组合物和式（I）化合物多晶型的工艺。
• Oral care compositions
  申请人：FIRMENICH SA

  公开号：US11389383B2

  公开（公告）日：2022-07-19

  The various aspects presented herein relate to oral care compositions comprising: a) a bioactive component in an amount from 0.01 to 10 wt % of the oral care composition; b) a non-ionic surfactant comprising (i) a surfactant selected from the group consisting of: poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers, poly(oxyethylene)-modified hydrogenated castor oils, and poly(oxyethylene)-modified fatty acid monoesters of sorbitan, and (ii) a surfactant selected from the group consisting of polyol esters and sugar esters; c) at least one orally acceptable solvent; and optionally, d) a C2-C4 monohydric alcohol, wherein the ratio of the surfactant selected from the group consisting of: poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) block copolymers, poly(oxyethylene)-modified hydrogenated castor oils, and poly(oxyethylene)-modified fatty acid monoesters of sorbitan to the surfactant selected from the group consisting of polyol esters and sugar esters is from 1:10 to 10:1; and wherein the ratio of the non-ionic surfactant to the bioactive component is from 0.5 to 3.

  本文介绍的各个方面涉及口腔护理组合物，其中包括： a) 生物活性成分，其用量占口腔护理组合物的 0.b) 非离子表面活性剂，包括(i) 选自以下组别的表面活性剂聚(氧乙烯)-聚(氧丙烯)-聚(氧乙烯)嵌段共聚物、聚(氧乙烯)改性氢化蓖麻油和聚(氧乙烯)改性山梨醇脂肪酸单酯，以及 (ii) 选自多元醇酯和糖酯组成的组的表面活性剂；c) 至少一种口服可接受溶剂；以及 d) C2-C4 一元醇，其中表面活性剂的比例选自由以下物质组成的组：聚(氧乙烯)-聚(氧丙烯)-聚(氧乙烯)嵌段共聚物、聚(氧乙烯)改性氢化蓖麻油和聚(氧乙烯)改性山梨醇脂肪酸单酯与选自由多元醇酯和糖酯组成的组的表面活性剂的比例为 1:10 至 10:1；其中非离子表面活性剂与生物活性组分的比例为 0.5 至 3。
• COOLING COMPOSITIONS CONTAINING AN AMIDE AND AN ALKYL LACTATE
  申请人：Firmenich SA

  公开号：EP3652171B1

  公开（公告）日：2021-09-08
• SUNSCREEN WITH COOLING AGENT
  申请人：THE DIAL CORPORATION

  公开号：US20140161846A1

  公开（公告）日：2014-06-12

  A sunscreen formulation and methods for making the same include a sunscreen compound into which is added a cooling agent. The cooling agent will produce a cooling or cooling sensation when experienced by a user of the sunscreen. A controlled release mechanism is used to delay activation of the cooling agent.