[(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl] methanesulfonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl] methanesulfonate
• 化学式: C₁₀H₁₆O₄S
• 分子量: 232.3
• InChiKey: WCIWAEVXQSYRML-GMSGAONNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Polymorph of rucaparib camsylate
  申请人：SHANGHAI BEGREAT PHARMATECH

  公开号：US11352362B2

  公开（公告）日：2022-06-07

  The present disclosure may disclose a new crystal form D of 8-fluoro-2-4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl) methanesulfonic acid salt, preparation method therefor and a medicinal use. Compared to the existing crystalline forms, this new crystalline form has clear advantages with respect to solubility, stability, and the preparation process.

  本公开可披露一种 8-氟-2-4-[(甲基氨基)甲基]苯基}-1,3,4,5-四氢-6H-氮杂卓[5,4,3-cd]吲哚-6-酮（(1S,4R)-7,7-二甲基-2-氧代双环[2.2.1]庚-1-基）甲磺酸盐的新晶型 D 及其制备方法和药用用途。与现有的结晶形式相比，这种新的结晶形式在溶解性、稳定性和制备工艺方面具有明显的优势。
• POLYMORPH OF RUCAPARIB CAMSYLATE AND PREPARATION METHOD THEREOF AND USE OF SAME
  申请人：SHANGHAI BEGREAT PHARMATECH

  公开号：US20200291036A1

  公开（公告）日：2020-09-17

  The present disclosure may disclose a new crystal form D of 8-fluoro-2-4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl) methanesulfonic acid salt, preparation method therefor and a medicinal use. Compared to the existing crystalline forms, this new crystalline form has clear advantages with respect to solubility, stability, and the preparation process.
• US8952204B2
  申请人：——

  公开号：US8952204B2

  公开（公告）日：2015-02-10