[(2S,3R)-1-[[(1R,2R,3S,4R,9R,10R,11R,12S,13S,15R)-4-acetyloxy-1,9,11,12-tetrahydroxy-2-[hydroxy(phenyl)methoxy]-10,14,17,17-tetramethyl-6-oxatetracyclo[11.3.1.03,10.04,7]heptadecan-15-yl]oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxo-3-phenylpropan-2-yl] 3-oxocyclopentane-1-carboxylate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(2S,3R)-1-[[(1R,2R,3S,4R,9R,10R,11R,12S,13S,15R)-4-acetyloxy-1,9,11,12-tetrahydroxy-2-[hydroxy(phenyl)methoxy]-10,14,17,17-tetramethyl-6-oxatetracyclo[11.3.1.03,10.04,7]heptadecan-15-yl]oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxo-3-phenylpropan-2-yl] 3-oxocyclopentane-1-carboxylate
• 化学式: C₄₉H₆₅NO₁₆
• 分子量: 924.0
• InChiKey: GXWRLERMPKNTHF-CVQUOPOJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  66
• 可旋转键数：
  16
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  254
• 氢给体数：
  6
• 氢受体数：
  16

文献信息

• MACROMOLECULES
  申请人：Owen David

  公开号：US20140171375A1

  公开（公告）日：2014-06-19

  The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
• US9744246B2
  申请人：——

  公开号：US9744246B2

  公开（公告）日：2017-08-29