(4E,8E)-10-chloro-4,8-dimethyldeca-4,8-dien-1-amine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4E,8E)-10-chloro-4,8-dimethyldeca-4,8-dien-1-amine
• 化学式: C₁₂H₂₂ClN
• 分子量: 215.76
• InChiKey: ULQALIHZSVXKEN-QAZZFAKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• PROTEIN-ACTIVE AGENT CONJUGATES AND METHOD FOR PREPARING THE SAME
  申请人：LegoChem Biosciences, Inc.

  公开号：EP3610889A1

  公开（公告）日：2020-02-19

  The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates, as well as methods for making the conjugates and compositions. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).

  本发明提供了具有可被异戊二烯转移酶识别的氨基酸基团的蛋白质-活性剂共轭物。本发明还提供了含有该共轭物的组合物，以及制造该共轭物和组合物的方法。本发明进一步提供了使用共轭物将活性剂递送至靶细胞的方法，以及使用共轭物治疗有需要的受试者（如需要活性剂的受试者）的方法。
• Methods of preparing antibody-active agent conjugates
  申请人：LegoChem Biosciences, Inc.

  公开号：US20140187756A1

  公开（公告）日：2014-07-03

  The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agent. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.