(Z)-3-(4-methoxyphenyl)-1,5-diphenylpent-2-en-4-yn-1-ol | 896106-08-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-3-(4-methoxyphenyl)-1,5-diphenylpent-2-en-4-yn-1-ol
• CAS: 896106-08-4
• 化学式: C₂₄H₂₀O₂
• 分子量: 340.422
• InChiKey: YQWXUCVBGICBOY-RELWKKBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-3-(4-methoxyphenyl)-1,5-diphenylpent-2-en-4-yn-1-ol 、 乙酸酐 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (Z)-3-(4-methoxyphenyl)-1,5-diphenylpent-2-en-4-yn-1-yl acetate
  参考文献：
  名称：

  Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation

  摘要：

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.018
• 作为产物：
  描述：

  4-甲氧基苯甲醛 、 苯乙炔 在 potassium tert-butylate 、 硫酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 0.05h， 生成 (Z)-3-(4-methoxyphenyl)-1,5-diphenylpent-2-en-4-yn-1-ol
  参考文献：
  名称：

  Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes tuned by gold(i) and silver(i) catalysts: efficient synthesis of pyran-fused indene cores and 2,4,6-trisubstituted phenols

  摘要：

  文中描述了顺式-2-酰基-1-炔基-1-芳基环丙烷 1 在金（I）和银（I）催化剂作用下的串联反应，这些反应分别以良好的收率选择性地获得了关键的吡喃融合茚核 2 和 2,4,6-三取代酚 3。

  DOI：

  10.1039/b909181e

文献信息

• KO<i>^t</i>Bu-Promoted Three-Component Coupling of Aldehydes and Alkynes:  Highly Efficient Synthesis of 1-En-4-yn-3-ols and 2-En-4-yn-1-ols
  作者：Shao-Hua Wang、Yong-Qiang Tu、Peng Chen、Xiang-Dong Hu、Fu-Min Zhang、Ai-Xia Wang

  DOI：10.1021/jo0604078

  日期：2006.5.1

  A (KOBu)-Bu-t-promoted three-component coupling reaction of aldehydes and alkynes without a transition-metal catalyst was developed in which the sequential addition/isomerization/addition processes take place in one pot. This reaction could be developed into a straightforward and effective method for rapid access to stereodefined (E)-1-en-4-yn-3-ol and (Z)2-en-4-yn-1-ol compounds.
• Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes tuned by gold(i) and silver(i) catalysts: efficient synthesis of pyran-fused indene cores and 2,4,6-trisubstituted phenols
  作者：Xiao-Ming Zhang、Yong-Qiang Tu、Yi-Jun Jiang、Yong-Qiang Zhang、Chun-An Fan、Fu-Min Zhang

  DOI：10.1039/b909181e

  日期：——

  Tandem reactions of cis-2-acyl-1-alkynyl-1-aryl cyclopropanes 1 tuned by gold(I) and silver(I) catalysts are described, which afford selectively the key pyran-fused indene cores 2 and the 2,4,6-trisubstituted phenols 3 in good yields, respectively.

  文中描述了顺式-2-酰基-1-炔基-1-芳基环丙烷 1 在金（I）和银（I）催化剂作用下的串联反应，这些反应分别以良好的收率选择性地获得了关键的吡喃融合茚核 2 和 2,4,6-三取代酚 3。
• Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation
  作者：Yong-Jiang Bian、Xue-Yuan Liu、Ke-Gong Ji、Xing-Zhong Shu、Li-Na Guo、Yong-Min Liang

  DOI：10.1016/j.tet.2008.12.018

  日期：2009.2

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.