beta-D-Galactopyranosylphenyl isothiocyanate | 20721-62-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: beta-D-Galactopyranosylphenyl isothiocyanate
• 英文别名: 2-(hydroxymethyl)-6-(4-isothiocyanatophenoxy)oxane-3,4,5-triol
• CAS: 20721-62-4
• 化学式: C₁₃H₁₅NO₆S
• 分子量: 313.33
• InChiKey: RWANFUZQWINQBY-UHFFFAOYSA-N

物化性质

• 沸点：
  577.5±50.0 °C(Predicted)
• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  144
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 危险品标志：
  Xn

反应信息

• 作为反应物：
  描述：

  、 、 disodium;carbonate 、 beta-D-Galactopyranosylphenyl isothiocyanate 在 氯化钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 64.0h， 生成 D-甘露糖
  参考文献：
  名称：

  Serpin enzyme complex receptor-mediated gene transfer

  摘要：

  核酸被压缩，基本上不会聚集，以便它们被注射到生物体的目标细胞中。核酸可以通过基因表达、与不需要表达的内源性核酸杂交或位点特异性整合来实现临床效果，以替换、修改或删除目标基因。可以通过靶细胞结合基团增强定位。最好将核酸压缩到一种紧凑的状态。

  公开号：

  US06200801B1

文献信息

• Delivery of nucleic acid to cells
  申请人：Case Western Reserve University

  公开号：US05972900A1

  公开（公告）日：1999-10-26

  Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.

  核酸被压缩，且基本无聚集，以便于它们被注射到生物体的目标细胞中。核酸可以通过基因表达、与内源性核酸杂交（其表达不受欢迎），或位点特异性整合而产生临床效果，从而替换、修饰或删除目标基因。可以通过靶细胞结合基团增强定位。最好将核酸压缩成一种紧凑状态。
• Serpin enzyme complex receptor--mediated gene transfer
  申请人：Case Western Reserve University

  公开号：US05972901A1

  公开（公告）日：1999-10-26

  Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.

  核酸被压缩，实现无聚集，以便于其被注射到生物体的靶细胞中。这些核酸可能通过基因表达、杂交到不需要表达的内源性核酸或者位点特异性整合来实现临床效应，以替换、修改或删除目标基因。这种定向作用可以通过靶细胞结合基团来增强。核酸最好被压缩到一种紧凑的状态。
• US7544518B2
  申请人：——

  公开号：US7544518B2

  公开（公告）日：2009-06-09
• Serpin enzyme complex receptor-mediated gene transfer
  申请人：Case Western Reserve University

  公开号：US06200801B1

  公开（公告）日：2001-03-13

  Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.

  核酸被压缩，基本上不会聚集，以便它们被注射到生物体的目标细胞中。核酸可以通过基因表达、与不需要表达的内源性核酸杂交或位点特异性整合来实现临床效果，以替换、修改或删除目标基因。可以通过靶细胞结合基团增强定位。最好将核酸压缩到一种紧凑的状态。