N-Isobutyl-3-nitroquinolin-4-amine 4-Chloro-3-nitroquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-Isobutyl-3-nitroquinolin-4-amine 4-Chloro-3-nitroquinoline
• 英文别名: 4-chloro-3-nitroquinoline;N-(2-methylpropyl)-3-nitroquinolin-4-amine
• 化学式: C22H20ClN5O4
• 分子量: 453.9
• InChiKey: ILTYBSAWHQOSGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-硝基-4-羟基喹啉 、 异丁胺 、 4-氯-3-硝基喹啉 、 在 ammonium hydroxide 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以gave 6.49 g of product的产率得到
  参考文献：
  名称：

  AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY

  摘要：

  本文描述了对炎症、真菌、单细胞寄生微生物和癌症具有活性的胺化合物。这些化合物包含一个单环、双环或三环芳香环，其中含有一个、两个或三个环氮原子。

  公开号：

  US20150361077A1

文献信息

• Aminoquinazoline compounds having anti-inflammatory, antifungal, antiparasitic, and anticancer activity
  申请人：Wellstat Therapeutics Corporation

  公开号：US10934284B2

  公开（公告）日：2021-03-02

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.

  本文描述了具有抗炎、抗真菌、抗单细胞寄生微生物和抗癌活性的胺化合物。这些化合物含有单环、双环或三环芳香环，环上有一个、两个或三个氮原子。
• AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY
  申请人：Wellstat Therapeutics Corporation

  公开号：EP2950649B1

  公开（公告）日：2020-03-04
• AMINOQUINOLINE COMPOUNDS HAVING ANTICANCER ACTIVITY
  申请人：Wellstat Therapeutics Corporation

  公开号：US20180298000A1

  公开（公告）日：2018-10-18

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
• AMINOQUINAZOLINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY
  申请人：Wellstat Therapeutics Corporation

  公开号：US20190194193A1

  公开（公告）日：2019-06-27

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
• IMIDAZOQUINOLYL COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC, AND ANTICANCER ACTIVITY
  申请人：Wellstat Therapeutics Corporation

  公开号：US20210163476A1

  公开（公告）日：2021-06-03

  Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.