[(3R,6R)-6-methylpiperidin-3-yl]methyl (7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(3R,6R)-6-methylpiperidin-3-yl]methyl (7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)methanesulfonate
• 化学式: C₁₇H₂₉NO₄S
• 分子量: 343.5
• InChiKey: DTSFDOOVFJJKIL-GXZXJKLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  80.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PIPERIDINYL ALKYNE OREXIN RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20140243368A1

  公开（公告）日：2014-08-28

  The present invention is directed to piperidinyl alkyne compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the piperidinyl alkyne compounds described herein in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及对荷尔蒙受体拮抗剂的哌啶基炔化合物。本发明还涉及使用本文描述的哌啶基炔化合物在治疗或预防神经和精神障碍和疾病方面的用途，其中荷尔蒙受体参与其中。本发明还涉及包含这些化合物的制药组合物。本发明还涉及使用这些制药组合物在预防或治疗荷尔蒙受体参与的这些疾病方面的用途。
• OXAZOLE OREXIN RECEPTOR ANTAGONISTS
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US20160176858A1

  公开（公告）日：2016-06-23

  The present invention is directed to oxazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the oxazole compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to pharmaceutical compositions comprising these compounds. The present invention is also directed to uses of these pharmaceutical compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及噁唑化合物，其是促进睡眠的荷尔蒙受体的拮抗剂。本发明还涉及这些噁唑化合物在潜在的神经和精神障碍和疾病的治疗或预防中的应用，其中涉及到促进睡眠的荷尔蒙受体。本发明还涉及包含这些化合物的制药组合物。本发明还涉及这些制药组合物在预防或治疗涉及促进睡眠的荷尔蒙受体的疾病中的应用。
• US8940898B2
  申请人：——

  公开号：US8940898B2

  公开（公告）日：2015-01-27