tabulin | 41653-75-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: tabulin
• 英文别名: tatridin A；(3aS,4R,5E,9S,10E,11aS)-4,9-dihydroxy-6,10-dimethyl-3-methylidene-3a,4,7,8,9,11a-hexahydrocyclodeca[b]furan-2-one
• CAS: 41653-75-2
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.321
• InChiKey: YMNZWKHEJQGPIA-OBQKTHCVSA-N

物化性质

• 熔点：
  160-161 °C
• 沸点：
  496.4±45.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tabulin 、 二甲胺 以 乙醇 为溶剂， 反应 0.5h， 以90%的产率得到1,6-dihydroxy-7α,11α(H),1β,6β,8β(H)-4(5),10(9)-dien-13-dimethylaminogermacr-8,12-olide
  参考文献：
  名称：

  Aminoderivatives of sesquiterpene lactones from tanachin and tavulin and their biological activity

  摘要：

  Michael reaction of sesquiterpene lactones of tanachin and tavulin yield eight new aminoderivatives, the structures of which are confirmed by spectral methods. The anti,microbial activity of the synthesized compounds against certain strains of microorganisms and the inhibition of ion-transport enzymes in biological membranes are examined.

  DOI：

  10.1007/bf02238338

文献信息

• Aminoderivatives of sesquiterpene lactones from tanachin and tavulin and their biological activity
  作者：M. B. Izbosarov、Kh. T. Zairova、B. Kh. Abduazimov、V. M. Malikov

  DOI：10.1007/bf02238338

  日期：2000.5

  Michael reaction of sesquiterpene lactones of tanachin and tavulin yield eight new aminoderivatives, the structures of which are confirmed by spectral methods. The anti,microbial activity of the synthesized compounds against certain strains of microorganisms and the inhibition of ion-transport enzymes in biological membranes are examined.