tert-butyl 9-bromo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxylate | 1443411-62-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: tert-butyl 9-bromo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxylate
• 英文别名: Tert-butyl 6-bromo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7-triene-10-carboxylate；tert-butyl 6-bromo-1,10-diazatricyclo[6.4.1.04,13]trideca-4(13),5,7-triene-10-carboxylate
• CAS: 1443411-62-8
• 化学式: C₁₆H₂₁BrN₂O₂
• 分子量: 353.259
• InChiKey: QKWQTYOXYKVBBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl 9-bromo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxylate 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以49%的产率得到Tert-butyl 6-bromo-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-10-carboxylate
  参考文献：
  名称：

  METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION

  摘要：

  本发明涉及米诺地尔和Sonic Hedgehog (Shh)途径激活剂以及可选的Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞的自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。

  公开号：

  US20200121681A1
• 作为产物：
  描述：

  2-(5-bromo-1H-indole-1-yl)ethanamine 在 吡啶硼烷 、 硫酸 、 potassium carbonate 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 溶剂黄146 为溶剂， 反应 0.83h， 生成 tert-butyl 9-bromo-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-2(1H)-carboxylate
  参考文献：
  名称：

  METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION

  摘要：

  本发明涉及米诺地尔和Sonic Hedgehog (Shh)途径激活剂以及可选的Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞的自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。

  公开号：

  US20200121681A1

文献信息

• [EN] METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION<br/>[FR] PROCÉDÉS POUR LA PROLIFÉRATION DES CELLULES SOUCHES DES FOLLICULES PILEUX
  申请人：FREQUENCY THERAPEUTICS INC

  公开号：WO2018191350A1

  公开（公告）日：2018-10-18

  The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

  本发明涉及Sonic Hedgehog（Shh）通路激活剂和Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。
• [EN] 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS<br/>[FR] COMPOSÉS 1H-PYRROLE-2,5-DIONE ET LEURS PROCÉDÉS D'UTILISATION POUR INDUIRE UN AUTO-RENOUVELLEMENT DE CELLULES DE SUPPORT SOUCHES/PROGÉNITRICES
  申请人：FREQUENCY THERAPEUTICS INC

  公开号：WO2018125746A1

  公开（公告）日：2018-07-05

  The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.

  本发明涉及1H-吡咯-2,5-二酮化合物以及利用它们诱导干/祖细胞支持细胞自我更新的方法，包括诱导干/祖细胞增殖，同时在子细胞中保持分化为组织细胞的能力。
• Characterization of Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis
  作者：Hendra Gunosewoyo、Andrew Midzak、Irina N. Gaisina、Emily V. Sabath、Allison Fedolak、Taleen Hanania、Dani Brunner、Vassilios Papadopoulos、Alan P. Kozikowski

  DOI：10.1021/jm400511s

  日期：2013.6.27

  Inhibition of GSK-3 beta has been well documented to account for the behavioral actions of the mood stabilizer lithium in various animal models of mood disorders. Recent studies have showed that genetic or pharmacological inhibition of GSK-3 beta resulted in anxiolytic-like and pro-social behavior. In our ongoing efforts to develop GSK-3 beta inhibitors for the treatment of mood disorders, SAR studies on maleimide-based compounds were undertaken. We present herein for the first time that some of these GSK-3 beta inhibitors, in particular analogues 1 and 9, were able to stimulate progesterone production in the MA-10 mouse tumor Leydig cell model of steroidogenesis without any significant toxicity. These two compounds were tested in the SmartCube behavioral assay and showed anxiolytic-like signatures following daily dose administration (50 mg/kg, ip) for 13 days. Taken together, these results support the hypothesis that GSK-3 beta inhibition could influence neuroactive steroid production thereby mediating the modulation of anxiety-like behavior in vivo.
• METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION
  申请人：Frequency Therapeutics, Inc.

  公开号：US20200121681A1

  公开（公告）日：2020-04-23

  The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

  本发明涉及米诺地尔和Sonic Hedgehog (Shh)途径激活剂以及可选的Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞的自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。