2-Methyl-5-(2-methyl-4-propan-2-ylphenyl)-1,3,4-oxadiazole

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-Methyl-5-(2-methyl-4-propan-2-ylphenyl)-1,3,4-oxadiazole
• 英文别名: 2-methyl-5-(2-methyl-4-propan-2-ylphenyl)-1,3,4-oxadiazole
• 化学式: C₁₃H₁₆N₂O
• 分子量: 216.28
• InChiKey: CAWHSDJNSSQUCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• US20140256756A1
  申请人：——

  公开号：US20140256756A1

  公开（公告）日：2014-09-11
• AZAINDOLE INHIBITORS OF WILD-TYPE AND MUTANT FORMS OF LRRK2
  申请人：DANA-FARBER CANCER INSTITUTE, INC.

  公开号：US20210347772A1

  公开（公告）日：2021-11-11

  Disclosed are compounds that possess inhibitory activity against LRRK2. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat diseases and disorders including neurodegenerative diseases and disorders such as Parkinson's disease, and brain cancer (e.g., gliomas and glioblastomas).