(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal;(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal;(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
• 化学式: C37H51NO2
• 分子量: 541.8
• InChiKey: MQYQTQCKJURWDK-BYSUDIFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  40
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NICOTINAMIDE MONONUCLEOTIDE DERIVATIVES AND THEIR USES<br/>[FR] DÉRIVÉS DE NICOTINAMIDE MONONUCLÉOTIDE ET LEUR UTILISATIONS
  申请人：METROBIOTECH LLC

  公开号：WO2017024255A1

  公开（公告）日：2017-02-09

  The invention relates to compositions of nicotinamide mononucleotide derivatives and their methods of use. The invention also relates to methods of preparing nicotinamide mononucleotide derivatives. The invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinamide mononucleotide derivative. The invention relates to methods of using nicotinamide mononucleotide derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for treating diseases and improving cell and tissue survival.

  本发明涉及烟酰胺单核苷酸衍生物的组合物及其使用方法。本发明还涉及制备烟酰胺单核苷酸衍生物的方法。本发明涉及含有烟酰胺单核苷酸衍生物的药物组合物和营养补充剂。本发明涉及使用烟酰胺单核苷酸衍生物的方法，促进细胞和组织中烟酰胺腺嘌呤二核苷酸（NAD+）水平的增加，用于治疗疾病和改善细胞和组织的存活。
• [EN] NICOTINAMIDE RIBOSIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF<br/>[FR] ANALOGUES DE NICOTINAMIDE RIBOSIDE, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS ASSOCIÉES
  申请人：METRO INT BIOTECH LLC

  公开号：WO2019152416A1

  公开（公告）日：2019-08-08

  Provided herein are compounds of Formula (I) and their salts, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating, for example, diseases or disorders related to aging or stress, diabetes, obesity, mitochondrial diseases, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing.

  本文提供了公式（I）的化合物及其盐，以及包含这些化合物的组合物，这些化合物对于增加细胞中NAD+的数量是有用的。还公开了使用所述化合物和组合物治疗与衰老或压力有关的疾病或障碍，糖尿病，肥胖症，线粒体疾病，神经退行性疾病，心血管疾病，血液凝块障碍，炎症，癌症和/或潮红的方法。
• Crystal forms of beta-nicotinamide mononucleotide
  申请人：Metro International Biotech, LLC

  公开号：US10233208B1

  公开（公告）日：2019-03-19

  The invention relates to crystalline forms of a β-nicotinamide mononucleotide, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for nutraceutical, veterinary, and agriculturally-relevant uses.

  本发明涉及β-烟酰胺单核苷酸的结晶形式、其制备方法以及相关药物制剂。本发明还涉及适用于营养保健、兽医和农业相关用途的制剂。
• Administration of nicotinamide mononucleotide in the treatment of disease
  申请人：Washington University

  公开号：US10258638B2

  公开（公告）日：2019-04-16

  Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.

  本发明公开了与治疗、改善、减轻、减缓、阻止、预防或逆转各种疾病和病症有关的方法和组合物，这些疾病和病症包括与年龄有关的肥胖、与年龄有关的血脂水平升高、与年龄有关的胰岛素敏感性降低、与年龄有关的记忆功能降低以及与年龄有关的眼睛功能变化，如黄斑变性。这些方法包括向受试者施用烟酰胺单核苷酸（NMN）。在某些实施方案中，给药可以是口服给药。还公开了包含 NMN 的药物组合物。
• Crystal forms of β-nicotinamide mononucleotide
  申请人：Metro International Biotech, LLC

  公开号：US10392415B2

  公开（公告）日：2019-08-27

  The invention relates to crystalline forms of a β-nicotinamide mononucleotide, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for nutraceutical, veterinary, and agriculturally-relevant uses.

  本发明涉及β-烟酰胺单核苷酸的结晶形式、其制备方法以及相关药物制剂。本发明还涉及适用于营养保健、兽医和农业相关用途的制剂。