色烯卡二乙胺 | 23915-80-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 色烯卡二乙胺
• 英文名称: 4-oxo-4H-1-benzopyran-2-carboxylic acid, compound with diethylamine (1:1)
• 英文别名: Diaethylamin；Diethylazanium;4-oxochromene-2-carboxylate；diethylazanium;4-oxochromene-2-carboxylate
• CAS: 23915-80-2
• 化学式: C₄H₁₁N*C₁₀H₆O₄
• 分子量: 263.293
• InChiKey: BTDWBTIPKMIUHM-UHFFFAOYSA-N

物化性质

• 熔点：
  138°

计算性质

• 辛醇/水分配系数(LogP)：
  2.11
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2922509090

文献信息

• Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders
  申请人：ZeaVision LLC

  公开号：US10307384B2

  公开（公告）日：2019-06-04

  Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.

  本发明公开了用于促进眼睛健康，特别是用于预防或治疗黄斑变性的口服制剂，其中含有类胡萝卜素色素玉米黄质和至少两种或两种以上额外的眼部活性营养素，这些营养素选自硫辛酸、ω-3 脂肪酸、植物源化合物（如类黄酮、花青素或多酚）、牛磺酸、肉碱、辅酶-Q10、肌肽和刺激谷胱甘肽生成的营养素。本研究公开了用于确定眼部活性营养素的方法，这些营养素将以协同和增效的方式与玉米黄质相互作用，为眼睛健康提供比玉米黄质单独作用更好、更有效的保护。其他可选成分包括锌、维生素 E 和维生素 C。
• Zeaxanthin formulations with additional ocular-active nutrients,for protecting eye health and treating eye disorders
  申请人：ZeaVision LLC

  公开号：US11045431B1

  公开（公告）日：2021-06-29

  Oral formulations for promoting eye health, and in particular for preventing or treating macular degeneration, are disclosed, containing zeaxanthin, a carotenoid pigment, and at least two or more additional ocular-active nutrients selected from lipoic acid, omega-3 fatty acids, plant-derived compounds such as flavonoids, anthocyanins, or polyphenolics, taurine, carnitine, Coenzyme-Q10, carnosine, and nutrients that stimulate the production of glutathione. Processes are disclosed for identifying ocular-active nutrients that will interact in a synergistic and potentiating manner with zeaxanthin, to provide better and more effective protection, for eye health, than can be provided by zeaxanthin alone. Additional optional agents include zinc, vitamin E, and vitamin C.

  本发明公开了用于促进眼睛健康，特别是用于预防或治疗黄斑变性的口服制剂，其中含有类胡萝卜素色素玉米黄质和至少两种或两种以上额外的眼部活性营养素，这些营养素选自硫辛酸、ω-3 脂肪酸、植物源化合物（如类黄酮、花青素或多酚）、牛磺酸、肉碱、辅酶-Q10、肌肽和刺激谷胱甘肽生成的营养素。本研究公开了用于确定眼部活性营养素的方法，这些营养素将以协同和增效的方式与玉米黄质相互作用，为眼睛健康提供比玉米黄质单独作用更好、更有效的保护。其他可选成分包括锌、维生素 E 和维生素 C。
• Ocular formulations with neuroprotectants to reduce Alzheimer and neurotoxic risks created by large zinc dosages
  申请人：Gierhart L. Dennis

  公开号：US20060039954A1

  公开（公告）日：2006-02-23

  Formulations marketed to elderly consumers for preventing or treating age-related eye diseases such as macular degeneration are modified in various four ways, compared to the formulations tested in the first “Age-Related Eye Disease Study” (AREDS-1) clinical trial. Zinc dosages are substabtially reduced, to reduce the risk of Alzheimer's disease and other neurotoxic damage in the brains of elderly people, and zeaxanthin is substituted for a substantial portion of any beta-carotene. Additional useful agents are also disclosed.

  与首次 "老年性眼病研究"（AREDS-1）临床试验中的配方相比，面向老年消费者销售的用于预防或治疗黄斑变性等老年性眼病的配方在四个方面进行了不同程度的修改。 锌的用量部分减少，以降低阿尔茨海默病和老年人大脑中其他神经毒性损伤的风险，玉米黄质取代了大部分的β-胡萝卜素。 还公开了其他有用的制剂。
• INHIBITION OF TUMOR NECROSIS FACTOR ALPHA
  申请人：MARGOLIN, Solomon B.

  公开号：EP0866656A1

  公开（公告）日：1998-09-30
• EP0866656A4
  申请人：——

  公开号：EP0866656A4

  公开（公告）日：2001-05-23