2-[5-methyl-2-(trifluoromethyl)-4-pyridyloxy]acetamide | 340809-51-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[5-methyl-2-(trifluoromethyl)-4-pyridyloxy]acetamide
• 英文别名: 2-[5-Methyl-2-(trifluoromethyl)pyridin-4-yl]oxyacetamide
• CAS: 340809-51-0
• 化学式: C₉H₉F₃N₂O₂
• 分子量: 234.178
• InChiKey: AGRNHNVESKTWKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  65.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[5-methyl-2-(trifluoromethyl)-4-pyridyloxy]acetamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以92%的产率得到4-amino-5-methyl-2-(trifluoromethyl)pyridine
  参考文献：
  名称：

  Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines

  摘要：

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00024-2
• 作为产物：
  描述：

  5-methyl-2-trifluoromethyl-4H-pyran-4-one 在 ammonium hydroxide 、 potassium carbonate 、 sodium iodide 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 48.0h， 生成 2-[5-methyl-2-(trifluoromethyl)-4-pyridyloxy]acetamide
  参考文献：
  名称：

  Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines

  摘要：

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00024-2

文献信息

• Synthesis of 5-alkyl-4-amino-2-(trifluoromethyl)pyridines and their transformation into trifluoromethylated 1 H -pyrazolo[4,3- c ]pyridines
  作者：Vladimir I Tyvorskii、Denis N Bobrov、Oleg G Kulinkovich、Kourosch Abbaspour Tehrani、Norbert De Kimpe

  DOI：10.1016/s0040-4020(01)00024-2

  日期：2001.3

  5-Alkyl-4-amino-2-(trifluoromethyl)pyridines were prepared in good yields starting from the corresponding pyridinols either using condensation with tosyl isocyanate or by alkylation with 2-chloroacetamide and subsequent Smiles type rearrangement. The cyclisation of diazonium salts, generated from 5-alkyl-4-amino-2-(trifluoromethyl)pyridines afforded trifluoromethylated 1H-pyrazolo[4,3-c] pyri dines. (C) 2001 Elsevier Science Ltd. All rights reserved.