4-(2-phenyl-1H-indol-3-yl)-3-cyclohexene-1,1-dicarboxylic acid | 93503-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(2-phenyl-1H-indol-3-yl)-3-cyclohexene-1,1-dicarboxylic acid
• 英文别名: 4-(2-Phenyl-1H-indol-3-yl)cyclohex-3-ene-1,1-dicarboxylic acid
• CAS: 93503-52-7
• 化学式: C₂₂H₁₉NO₄
• 分子量: 361.397
• InChiKey: LMMMWJNDVTWHSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-phenyl-1H-indol-3-yl)-3-cyclohexene-1,1-dicarboxylic acid 在 钯 乙醚 、 正己烷 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以hexane to give 4.0 g (74%) of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1,1-dicarboxylic acid, m.p. 196°-197° C.的产率得到4-(2-phenyl-1H-indol-3-yl)cyclohexane-1,1-dicarboxylic acid
  参考文献：
  名称：

  2-Phenylindole derivatives, their use as complement inhibitors

  摘要：

  4-(1-R'-2-苯基-1H-吲哚-3-基)-3-环己烯-1-羧酸，4-(1'R'-2-苯基-1H-吲哚-3-基)环己烷-1-羧酸，4-(1-R'-2-苯基-1H-吲哚-3-基)苯甲酸，相应的环己烯和环己烷-1,1-二羧酸，以及其低烷基酯，其中R'为氢或低烷基，通过将1-R'-2-苯基-1H-吲哚与环己酮-4-羧酸或-4,4-二羧酸反应制备而成，然后根据需要进行氢化或芳香化处理。这些化合物中的自由羧酸或其盐可用作补体抑制剂。相应的酯可用作中间体。

  公开号：

  US04510158A1
• 作为产物：
  描述：

  2-苯基吲哚 、 cyclohexanone-4,4-dicarboxylic acid 在 磷酸 、 乙酸酐 、 溶剂黄146 作用下， 反应 72.0h， 以42%的产率得到4-(2-phenyl-1H-indol-3-yl)-3-cyclohexene-1,1-dicarboxylic acid
  参考文献：
  名称：

  Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids

  摘要：

  The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs.

  DOI：

  10.1021/jm00380a002

文献信息

• 2-Phenylindole derivatives, their use as complement inhibitors
  申请人：Sterling Drug Inc.

  公开号：US04510158A1

  公开（公告）日：1985-04-09

  4-(1-R'-2-phenyl-1H-indol-3-yl)-3-cyclohexene-1-carboxylic acids, 4-(1'R'-2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids, 4-(1-R'-2-phenyl-1H-indol-3-yl)benzoic acids, the corresponding cyclohexene- and cyclohexane-1,1-dicarboxylic acids, and lower-alkyl esters thereof, wherein R' is hydrogen or lower-alkyl, are prepared by reacting a 1-R'-2-phenyl-1H-indole with a cyclohexanone-4-carboxylic acid or -4,4-dicarboxylic acid, followed as desired by a hydrogenation or aromatization process. The compounds which are free carboxylic acids or salts thereof are useful as complement inhibitors. The corresponding esters are useful as intermediates.

  通过将1-R'-2-苯基-1H-吲哚与环己酮-4-羧酸或-4,4-二羧酸反应，然后根据需要进行氢化或芳构化处理，制备4-(1-R'-2-苯基-1H-吲哚-3-基)-3-环己烯-1-羧酸、4-(1'R'-2-苯基-1H-吲哚-3-基)环己烷-1-羧酸、4-(1-R'-2-苯基-1H-吲哚-3-基)苯甲酸，相应的环己烯-和环己烷-1,1-二羧酸以及它们的低烷基酯。其中R'是氢或低烷基。这些化合物中的游离羧酸或其盐可用作补体抑制剂。相应的酯可用作中间体。
• BAILEY, D. M.;DEGRAZIA, G. D.;ALEXANDER, E. J.;POWLES, R. G.;JOHNSON, R. +, J. MED. CHEM., 1985, 28, N 2, 160-164
  作者：BAILEY, D. M.、DEGRAZIA, G. D.、ALEXANDER, E. J.、POWLES, R. G.、JOHNSON, R. +

  DOI：——

  日期：——
• US4510158A
  申请人：——

  公开号：US4510158A

  公开（公告）日：1985-04-09
• Syntheses and complement inhibitory activities of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids
  作者：Denis M. Bailey、George D. DeGrazia、E. John Alexander、Ronald G. Powles、Robert E. Johnson、Richard A. Patrick、Barbara G. Heerdt、Margo E. Fairbain、Donald J. Pruden

  DOI：10.1021/jm00380a002

  日期：1985.2

  The syntheses of 4-(2-phenyl-1H-indol-3-yl)cyclohexane-1-carboxylic acids are described. These compounds express potent in vitro inhibition of the human classical complement pathway, and qualitative SAR have been determined. Several of the in vitro active compounds also suppressed the complement dependent reverse passive Arthus reaction (RPAR) in guinea pigs.