4-(2,5-Dihydroxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-(2,5-Dihydroxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutanamide
• 英文别名: 4-(2,5-dihydroxy-3,4,6-trimethylphenyl)-2-hydroxy-2-methylbutanamide
• 化学式: C₁₄H₂₁NO₄
• 分子量: 267.32
• InChiKey: INXDVLVSFVYXGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• METHODS FOR CHIRAL RESOLUTION OF TROLOX
  申请人：BIOELECTRON TECHNOLOGY CORPORATION

  公开号：EP3233819A1

  公开（公告）日：2017-10-25
• US9169196B2
  申请人：——

  公开号：US9169196B2

  公开（公告）日：2015-10-27
• [EN] METHODS FOR CHIRAL RESOLUTION OF TROLOX<br/>[FR] PROCÉDÉS DE RÉSOLUTION CHIRALE DU TROLOX
  申请人：EDISON PHARMACEUTICALS INC

  公开号：WO2016100576A1

  公开（公告）日：2016-06-23

  The invention relates to methods of separating Trolox isomers (R)-Trolox and (S)-Trolox, comprising: (a) contacting a mixture of (R) and (S)-Trolox with a resolving agent selected from the group consisting of (1S,2S)-(+)-Pseudoephedrine, (R)-(+)-2-Amino-3-phenyl-1-propanol, (1R,2R)-(-)-Pseudoephedrine, and (S)-(-)-2-Amino-3-phenyl-1-propanol, wherein the resolving agent forms a solid salt with one of (R)-Trolox and (S)-Trolox, and substantially does not form a solid salt with the other; and (b) separating the solid salt from the Trolox isomer that did not form the solid salt with the resolving agent.