7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-3-(trifluoromethyl)octa-2,4,6-trienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-[2-Butoxy-3,5-di(propan-2-yl)phenyl]-3-(trifluoromethyl)octa-2,4,6-trienoic acid
• 英文别名: 7-[2-butoxy-3,5-di(propan-2-yl)phenyl]-3-(trifluoromethyl)octa-2,4,6-trienoic acid
• 化学式: C₂₅H₃₃F₃O₃
• 分子量: 438.5
• InChiKey: VUOSOCHNOBGHIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Fluorinated trienes and their use as rxr modulators
  申请人：——

  公开号：US20040248919A1

  公开（公告）日：2004-12-09

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis. 1

  本发明涉及一种调节哺乳动物中视黄醇X受体活性的方法，用于调节哺乳动物中视黄醇X受体活性的新型化合物和制备调节哺乳动物中视黄醇X受体活性的化合物的方法。这些化合物由结构式1表示：结构式1的化合物是有效的胰岛素敏化剂，并且不具有增加三酰甘油或抑制甲状腺激素轴的不良副作用。
• FLUORINATED TRIENES AND THEIR USE AS RXR MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1368296A1

  公开（公告）日：2003-12-10
• [EN] FLUORINATED TRIENES AND THEIR USE AS RXR MODULATORS<br/>[FR] TRIENES FLUORES ET LEUR UTILISATION EN TANT QUE MODULATEURS DE RXR
  申请人：LILLY CO ELI

  公开号：WO2002072528A1

  公开（公告）日：2002-09-19

  The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.