Tetracyclo[5.2.1.03,8.05,8]decane-1-carbonyl chloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Tetracyclo[5.2.1.03,8.05,8]decane-1-carbonyl chloride
• 英文别名: tetracyclo[5.2.1.03,8.05,8]decane-1-carbonyl chloride
• 化学式: C₁₁H₁₃ClO
• 分子量: 196.67
• InChiKey: NNAONZSMNUNWAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] BENZIMIDAZOLE COMPOUNDS AND USE THEREOF FOR TREATING ALZHEIMER'S DISEASE OR HUNTINGTON'S DISEASE<br/>[FR] COMPOSÉS DE BENZIMIDAZOLE ET LEUR UTILISATION POUR TRAITER LA MALADIE D'ALZHEIMER OU LA MALADIE DE HUNTINGTON
  申请人：SHIH CHUAN

  公开号：WO2020047360A1

  公开（公告）日：2020-03-05

  Benzimidazole compounds of formula (I), shown below, are disclosed. The compounds are potent human glutaminyl cyclase inhibitors. Also disclosed is a pharmaceutical composition containing one of these compounds and a pharmaceutical acceptable carrier, as well as a method of treating Alzheimer's disease or Huntington's disease by administering to a subject in need thereof an effective amount of such a compound.