7-Dimethylamino-3-methyl-quinoline-2,4-diol | 114058-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-Dimethylamino-3-methyl-quinoline-2,4-diol
• 英文别名: 2,4-Quinolinediol, 7-(dimethylamino)-3-methyl-；7-(dimethylamino)-4-hydroxy-3-methyl-1H-quinolin-2-one
• CAS: 114058-60-5
• 化学式: C₁₂H₁₄N₂O₂
• 分子量: 218.255
• InChiKey: XPQWPECKQDBFCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-Dimethylamino-3-methyl-quinoline-2,4-diol 在 三氯氧磷 作用下， 反应 1.0h， 以77%的产率得到(2,4-Dichloro-3-methyl-quinolin-7-yl)-dimethyl-amine
  参考文献：
  名称：

  7-Aminoquinolines. A novel class of agents active against herpes viruses

  摘要：

  A series of 7-aminoquinoline derivatives was synthesized and evaluated for their capacity to produce cytotoxicity in KB cells and to inhibit the replication of herpes simplex virus (HSV) type 1. All compounds tested inhibited the replication of HSV-1 with 50% inhibitory concentrations in the range of 2-50 micrograms/mL. The antiviral activity of many compounds, however, was separated from cytotoxicity to replicating uninfected cells by only two- to fivefold higher than those required for antiviral activity. Nonetheless, six compounds (10, 28, 29, 32, 34, and 36) were identified in which the separation was greater than fivefold. All compounds examined were more potent inhibitors of viral DNA synthesis than the cellular DNA synthesis.

  DOI：

  10.1021/jm00402a016
• 作为产物：
  描述：

  N,N-二甲基间苯二胺 、 甲基丙二酸二乙酯 以75%的产率得到
  参考文献：
  名称：

  NASR, M.;DRACH, J. C.;SMITH, S. H.;SHIPMAN, CH. , (JR);BURCKHALTER, J. H., J. MED. CHEM., 31,(1988) N 7, C. 1347-1351

  摘要：

  DOI：

文献信息

• NASR, M.;DRACH, J. C.;SMITH, S. H.;SHIPMAN, CH. , (JR);BURCKHALTER, J. H., J. MED. CHEM., 31,(1988) N 7, C. 1347-1351
  作者：NASR, M.、DRACH, J. C.、SMITH, S. H.、SHIPMAN, CH. , (JR)、BURCKHALTER, J. H.

  DOI：——

  日期：——
• COMPOSITION DE TEINTURE D'OXYDATION DES FIBRES KERATINIQUES COMPRENANT UN ETHER DE CELLULOSE CATIONIQUE, UN METASILICATE ET DES COLORANTS D'OXYDATION, PROCEDE DE TEINTURE D'OXYDATION ET UTILISATION
  申请人：L'Oréal

  公开号：EP2182914A2

  公开（公告）日：2010-05-12
• COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES
  申请人：L'Oréal

  公开号：EP2175830A2

  公开（公告）日：2010-04-21
• [EN] COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES<br/>[FR] COMPOSITION DESTINÉE À LA COLORATION D'OXYDATION DE FIBRES KÉRATINIQUES, COMPRENANT UN ÉTHER CELLULOSIQUE CATIONIQUE, UN ESTER D'ACIDES GRAS ET DE SORBITAN FAIBLEMENT OXYÉTHYLÉNÉ ET DES COLORANTS D'OXYDATION
  申请人：OREAL

  公开号：WO2009016061A2

  公开（公告）日：2009-02-05

  The present invention relates to a dye composition comprising, in a medium suitable for dyeing: A) one or more particular cationic cellulose ether(s), B) one or more weakly oxyethylenated sorbitan fatty acid ester(s), and C) one or more oxidation dye(s). The present invention also relates to a process for dyeing keratin fibres using such a composition, and also to the use of this composition for dyeing keratin fibres.
• [EN] COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF<br/>[FR] COMPOSITION DE TEINTURE D'OXYDATION DES FIBRES KERATINIQUES COMPRENANT UN ETHER DE CELLULOSE CATIONIQUE, UN METASILICATE ET DES COLORANTS D'OXYDATION, PROCEDE DE TEINTURE D'OXYDATION ET UTILISATION
  申请人：OREAL

  公开号：WO2009019383A2

  公开（公告）日：2009-02-12

  La présente invention concerne une composition tinctoriale comprenant, dans un milieu approprié pour la teinture : A) un ou plusieurs éther(s) de cellulose cationique(s) particulier(s), B) un ou plusieurs métasilicate(s), et C) un ou plusieurs colorant(s) d'oxydation benzénique(s), hétérocyclique(s) ou naphtalénique(s). La présente invention concerne également un procédé de teinture des fibres kératiniques mettant en oeuvre une telle composition, ainsi que l'utilisation de cette composition pour la teinture des fibres kératiniques.