methyl 6,7-dideoxy-7-isothiocyanato-α-D-gluco-heptopyranoside | 263330-09-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6,7-dideoxy-7-isothiocyanato-α-D-gluco-heptopyranoside
• 英文别名: (2R,3S,4S,5R,6S)-2-(2-isothiocyanatoethyl)-6-methoxyoxane-3,4,5-triol
• CAS: 263330-09-2
• 化学式: C₉H₁₅NO₅S
• 分子量: 249.288
• InChiKey: GFRVGEABOMNHID-ZEBDFXRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 6,7-dideoxy-7-isothiocyanato-α-D-gluco-heptopyranoside 在 吡啶 作用下， 生成 N,N'-bis(methyl 2,3,4-tri-O-acetyl-6-deoxy-α-D-dlucopyranosid-6-yl)thiourea
  参考文献：
  名称：

  Sugar Thioureas as Anion Receptors. Effect of Intramolecular Hydrogen Bonding in the Carboxylate Binding Properties of Symmetric Sugar Thioureas

  摘要：

  DOI：

  10.1021/ol990889s
• 作为产物：
  描述：

  methyl α-D-gluco-heptopyranosidurononitrile 在 diborane-dimethylsulfide complex 、 calcium carbonate 作用下， 以 吡啶 、 乙二醇二甲醚 、 水 、 丙酮 为溶剂， 反应 31.0h， 生成 methyl 6,7-dideoxy-7-isothiocyanato-α-D-gluco-heptopyranoside
  参考文献：
  名称：

  Synthesis of 6,7-dideoxy-7-isothiocyanatoheptoses: stable fully unprotected monosaccharide isothiocyanates

  摘要：

  Methyl 6,7-dideoxy-7-isothiocyanato-alpha-D-gluco (manno)(galacto)-heptopyranosides have been synthesized in four steps by homologation of the respective methyl hexopyranosides via the corresponding heptopyranosydurononitriles. Neither intra- nor intermolecular thiocarbamate formation was observed, even under rather strenuous acidic or basic conditions. The reducing derivative 6,7-dideoxy-7-isothiocyanato-alpha-D-gluco-heptopyranose was also a stable compound in aqueous solution in the absence of base. Formation of a six-membered intramolecular cyclic thiocarbamate was achieved in DMF solution in the presence of triethylamine. The title compounds are the first examples of stable fully unprotected monosaccharide isothiocyanates.

  DOI：

  10.1016/s0008-6215(99)00273-6