methyl 4-[[(2R)-1-hydrazinyl-1-oxo-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propan-2-yl]amino]-4-oxobutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl 4-[[(2R)-1-hydrazinyl-1-oxo-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propan-2-yl]amino]-4-oxobutanoate
• 化学式: C₂₃H₃₉N₃O₄S
• 分子量: 453.6
• InChiKey: VAMOYCLPFQDXIG-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  136
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• ISOPRENYL COMPOUNDS AND METHODS THEREOF
  申请人：Stock Jeffry B.

  公开号：US20130310559A1

  公开（公告）日：2013-11-21

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  本发明提供了新型异戊烯基化合物，能够有效调节炎症反应，并且包括这些异戊烯基化合物的制药、化妆品、护肤品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或病症。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症以及用于治疗或预防与抑制炎症反应相关的疾病或病症的方法。
• Isoprenyl Compounds and Methods Thereof
  申请人：SIGNUM BIOSCIENCES, INC.

  公开号：US20160361283A1

  公开（公告）日：2016-12-15

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.
• US9376383B2
  申请人：——

  公开号：US9376383B2

  公开（公告）日：2016-06-28
• US9744147B2
  申请人：——

  公开号：US9744147B2

  公开（公告）日：2017-08-29