1-(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)-N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-N-methylmethanesulfonamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl)-N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-N-methylmethanesulfonamide
• 化学式: C₂₀H₃₆N₂O₄S
• 分子量: 400.6
• InChiKey: HZMFYJNISHUYQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• THERAPEUTIC DRUG FOR LIPID-PEROXIDATION-INDUCED DISEASES AND SCREENING METHOD FOR THERAPEUTIC DRUGS FOR LIPID-PEROXIDATION-INDUCED DISEASES
  申请人：Yamada, Ken-Ichi

  公开号：EP3650860A1

  公开（公告）日：2020-05-13

  The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.

  本发明提供了：一种使用式（I）代表的化合物作为荧光探针分子的检测方法，该方法用于检测受试化合物的脂质过氧化抑制活性；一种使用该检测方法的检测试剂盒；一种使用该检测方法的筛选方法；以及一种药物组合物，该药物组合物用于治疗由脂质过氧化反应诱发的疾病（如老年性黄斑变性）等。
• Therapeutic drug for lipid-peroxidation-induced diseases and screening method for therapeutic drugs for lipid-peroxidation-induced diseases
  申请人：Yamada Ken-ichi

  公开号：US11519893B2

  公开（公告）日：2022-12-06

  The present invention provides: an assay method that uses a compound represented by formula (I) as a fluorescent probe molecule and that is for detecting the lipid peroxidation suppression activity of a test compound; an assay kit that uses the assay method; a screening method that uses the assay method; and a pharmaceutical composition that is for the treatment, etc. of diseases (such as age-related macular degeneration) that are induced by lipid peroxidation reactions.

  本发明提供了：一种使用式（I）代表的化合物作为荧光探针分子的检测方法，该方法用于检测受试化合物的脂质过氧化抑制活性；一种使用该检测方法的检测试剂盒；一种使用该检测方法的筛选方法；以及一种药物组合物，该药物组合物用于治疗由脂质过氧化反应诱发的疾病（如老年性黄斑变性）等。