(S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-nitro-phenylcarbamoyl)-butyric acid | 56816-40-1

• 物质功能分类: 生物化工 - 多肽
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-nitro-phenylcarbamoyl)-butyric acid
• 英文别名: 2H-Isoindole-2-acetic acid, 1,3-dihydro-alpha-(3-((4-nitrophenyl)amino)-3-oxopropyl)-1,3-dioxo-, (S)-；(2S)-2-(1,3-dioxoisoindol-2-yl)-5-(4-nitroanilino)-5-oxopentanoic acid
• CAS: 56816-40-1
• 化学式: C₁₉H₁₅N₃O₇
• 分子量: 397.344
• InChiKey: YQMYCLQUUAANHT-HNNXBMFYSA-N

物化性质

• 沸点：
  724.4±60.0 °C(Predicted)
• 密度：
  1.557±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-nitro-phenylcarbamoyl)-butyric acid 在 肼 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 L-glutamic acid γ-p-nitroanilide methyl ester
  参考文献：
  名称：

  Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

  摘要：

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00083-0
• 作为产物：
  描述：

  L-谷氨酸 在 溶剂黄146 作用下， 以 苯 为溶剂， 生成 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-4-(4-nitro-phenylcarbamoyl)-butyric acid
  参考文献：
  名称：

  Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase

  摘要：

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00083-0

文献信息

• Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and Their kinetic studies with γ-Glutamyltranspeptidase
  作者：Christian Lherbet、Mylène Morin、Roselyne Castonguay、Jeffrey W Keillor

  DOI：10.1016/s0960-894x(03)00083-0

  日期：2003.3

  A new series Of L-glutamic acid p-nitroanilide analogues has been synthesized and tested as substrates and inhibitors of rat kidney gamma-glutamyltranspeptidase (GGT). Kinetic parameters (K-m and k(cat)) were determined for each analogue and provide insight into the scope and limits of GGT catalytic efficiency. (C) 2003 Elsevier Science Ltd. All rights reserved.