1-(2-morpholinophenyl)propan-1-one | 1430748-28-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-morpholinophenyl)propan-1-one
• 英文别名: 1-(2-Morpholin-4-ylphenyl)propan-1-one
• CAS: 1430748-28-9
• 化学式: C₁₃H₁₇NO₂
• 分子量: 219.283
• InChiKey: NSPBTYWVMQYOGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 1-(2-氟苯基)-2-丙烯-1-醇 在 RuH₂(CO)(PPh₃)₃ 、 双(2-二苯基磷苯基)醚 作用下， 以 二甲基亚砜 为溶剂， 反应 48.0h， 以35%的产率得到1-(2-morpholinophenyl)propan-1-one
  参考文献：
  名称：

  钌催化芳香碳的远程电子激活？F债券

  摘要：

  首次描述了烯丙基氟代苄基醇的串联异构化和亲核芳族取代。在钌络合物Ru（PPh 3）3（CO）（H）2存在下，1-（4-氟苯基）prop-2-en-1-ol被转化为相应的对氨基酮或对酚取代的酮。

  DOI：

  10.1002/adsc.201200879

文献信息

• Catalyst-free photodecarbonylation of <i>ortho</i>-amino benzaldehyde
  作者：Jingwei Zhou、Lamei Li、Songping Wang、Ming Yan、Wentao Wei

  DOI：10.1039/d0gc01256d

  日期：——

  strategy, we broke this consensus and discovered a catalyst-free photodecarbonylation of the aldehyde group. It revealed that decarbonylation can be easily achieved with visible light irradiation by introducing a tertiary amine into the ortho-position of the aldehyde group. A diverse array of tertiary amines is tolerated by our photodecarbonylation under mild conditions. Furthermore, the (QM) computations

  几乎共识是，醛基（–CHO）的脱羰不仅需要通过过渡金属催化剂来介导，而且还需要严格的反应条件（高温和长反应时间）。在这项工作中，受“基于构象选择性的”设计策略的启发，我们打破了这一共识，并发现了醛基的无催化剂光脱羰基。它表明，脱羰基化可以用可见光照射能够容易地实现通过引入叔胺到邻醛基的-位置。在温和条件下，我们的光脱羰基化可以耐受各种各样的叔胺。此外，在精心设计的特殊底物上进行机理和实验的（QM）计算表明，我们的光脱羰基取决于醛基和叔胺的构象特异性，并通过异常的[1,4] -H位移和随后的[1,3] -H移位。
• Photoreactive lenses
  申请人：GEC-MARCONI LIMITED

  公开号：EP0250193A2

  公开（公告）日：1987-12-23

  Photoreactive plastics lenses are disclosed which are coated or impregnated with an adamantane 2-spiro-benzo or naphthopyran and with a blue colouring pho tochromic benzo- or naphthopyran having a nitrogen containing substituent in the 2-position in the pyran ring. The lenses darken in sunlight and fade rapidly at ambient temperatures in the dark or in white light which does not contain a U.V. component. The combination of the yellow/orange colouring adamantane 2-spiro pyran compound with the purple/blue colouring pyran gives a desired brown/grey colouration in the sunlight-darkened lens. The invention includes novel blue-colouring pyran compounds in which the nitrogen-containing substituent in the 2-position is a phenyl group having an amino or substituted amino or nitrogen-containing heterocyclic substituent in the ortho- or para-position of the phenyl group.

  已公开的光活性塑料镜片涂有或浸渍有金刚烷 2-螺苯并吡喃或萘并吡喃，以及在吡喃环的 2 位上有含氮取代基的蓝色着色苯并吡喃或萘并吡喃。镜片在阳光下会变暗，在环境温度下，在黑暗或不含紫外线成分的白光中会迅速褪色。黄色/橙色着色金刚烷-2-螺吡喃化合物与紫色/蓝色着色吡喃化合物的组合使日光下变暗的镜片呈现出理想的棕色/灰色。本发明包括新型蓝色着色吡喃化合物，其中 2-位上的含氮取代基是苯基，苯基的正位或对位上有氨基或取代氨基或含氮杂环取代基。
• Crosslinked-interpenetrating networked block copolymer electrolytes for lithium batteries
  申请人：Robert Bosch GmbH

  公开号：US10879563B2

  公开（公告）日：2020-12-29

  A novel solid block copolymer electrolyte material is described. The material has first structural polymer blocks that make up a structural domain that has a modulus greater than 1×107 Pa at 25° C. There are also second ionically-conductive polymer blocks and a salt that make up an ionically-conductive domain adjacent to the structural domain. Along with the second ionically-conductive polymers, there is also a crosslinked network of third polymers, which interpenetrates the ionically-conductive domain. The third polymers are miscible with the second polymers. It has been shown that the addition of such an interpenetrating, crosslinked polymer network to the ionically-conductive domain improves the mechanical properties of the block copolymer electrolyte with no sacrifice in ionic conductivity.

  本文介绍了一种新型固体嵌段共聚物电解质材料。该材料具有第一结构聚合物块，它们构成了一个结构域，该结构域在 25 摄氏度时的模量大于 1×107 Pa；还具有第二离子导电聚合物块和一种盐，它们构成了与结构域相邻的离子导电域。除了第二种离子导电聚合物，还有第三种聚合物的交联网络，将离子导电域相互渗透。第三种聚合物可与第二种聚合物混溶。研究表明，在离子导电域中加入这种相互渗透的交联聚合物网络，可改善嵌段共聚物电解质的机械性能，而不会降低离子导电性。
• Urethane (meth)acrylate, method for manufacturing urethane (meth)acrylate, curable composition, cured article, and method for manufacturing cured article
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US10975191B2

  公开（公告）日：2021-04-13

  Provided is a urethane (meth)acrylate capable of achieving high strength and high elongation, as well as a method for manufacturing a urethane (meth)acrylate, a curable composition, a cured article, and a method for manufacturing a cured article. The urethane (meth)acrylate contains a structural unit derived from polycarbonate diol, a structural unit derived from polyisocyanate, and a hydroxy group-containing (meth)acrylate-derived group, the polycarbonate diol containing one or more types of structural unit represented by formula (1) wherein each of R1, R2, R3 and R4 independently represents an aliphatic hydrocarbon group having 1 to 6 carbon atoms.

  本发明提供了一种能够实现高强度和高伸长率的聚氨酯（甲基）丙烯酸酯，以及一种制造聚氨酯（甲基）丙烯酸酯的方法、一种可固化组合物、一种固化物和一种制造固化物的方法。聚氨酯（甲基）丙烯酸酯包含由聚碳酸酯二元醇衍生的结构单元、由多异氰酸酯衍生的结构单元和由含羟基的（甲基）丙烯酸酯衍生的基团，聚碳酸酯二元醇包含由式（1）表示的一种或多种结构单元，其中 R1、R2、R3 和 R4 各自独立地代表具有 1 至 6 个碳原子的脂肪族烃基。
• Method for connecting two objects using a polymer composition and a system, for use in a cosmetic procedure
  申请人：TSK Laboratory Europe B.V.

  公开号：US11091670B2

  公开（公告）日：2021-08-17

  The invention is directed to a method for using a polymer composition for connecting a first object to a second object, wherein the method comprises, the step of applying a polymer composition to at least part of the surface of at least one of the first object or second object; connecting the first object and the second object at the surface where the polymer composition is applied and irradiating the polymer composition using UV-radiation over a first time period, obtaining a UV radiated polymer composition; irradiating the UV radiated polymer composition with gamma-radiation over a second time period obtaining a gamma radiated polymer. The invention also relates to a system of a plastic object and a metal object connected by the method of the invention. In addition, the invention relates to a cosmetic method for anti-aging skin treatment wherein the method comprises the steps of: subcutaneously administering of an effective amount a of a dermal filler or Botulinum toxin to an area of skin, preferably the face and/or neck area, wherein the administering is performed by a syringe and a hypodermic needle or cannula of the invention.

  本发明涉及一种使用聚合物组合物连接第一物体和第二物体的方法，其中，该方法包括以下步骤：在第一物体或第二物体中的至少一个物体的至少部分表面涂抹聚合物组合物；在涂抹聚合物组合物的表面连接第一物体和第二物体，并在第一时间段内使用紫外线照射聚合物组合物，得到紫外线辐射聚合物组合物；在第二时间段内使用伽马射线照射紫外线辐射聚合物组合物，得到伽马射线辐射聚合物。本发明还涉及通过本发明方法连接塑料物体和金属物体的系统。此外，本发明还涉及一种用于抗衰老皮肤治疗的美容方法，其中该方法包括以下步骤：皮下注射有效量的皮肤填充剂或肉毒杆菌毒素到皮肤区域，最好是面部和/或颈部区域，其中注射是通过本发明的注射器和皮下注射针或套管进行的。