3-(1-Methoxy-1-methyl)ethoxy-2-(R)-methyl-1-propanol | 189217-51-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(1-Methoxy-1-methyl)ethoxy-2-(R)-methyl-1-propanol
• 英文别名: (2R)-3-(2-methoxypropan-2-yloxy)-2-methylpropan-1-ol
• CAS: 189217-51-4
• 化学式: C₈H₁₈O₃
• 分子量: 162.229
• InChiKey: WKIKPMJAEVRFJZ-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 3-(1-Methoxy-1-methyl)ethoxy-2-(R)-methyl-1-propanol 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以88%的产率得到[(2R)-3-(2-methoxypropan-2-yloxy)-2-methylpropoxy]methylbenzene
  参考文献：
  名称：

  Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)

  摘要：

  Enantioselective alkylation of chiral amide enolates derived From L-prolinol with beta-branched chiral iodides afforded good yields of hydroxy amide adducts. which were elaborated in four steps to give C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00334-8
• 作为产物：
  描述：

  Methyl 3-(1-Methoxy-1-methyl)ethoxy-2-(S)-methylpropionate 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以70%的产率得到3-(1-Methoxy-1-methyl)ethoxy-2-(R)-methyl-1-propanol
  参考文献：
  名称：

  Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)

  摘要：

  Enantioselective alkylation of chiral amide enolates derived From L-prolinol with beta-branched chiral iodides afforded good yields of hydroxy amide adducts. which were elaborated in four steps to give C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00334-8

文献信息

• US5684152A
  申请人：——

  公开号：US5684152A

  公开（公告）日：1997-11-04
• Chiral synthesis of C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3)
  作者：Mitree M. Ponpipom、William K. Hagmann

  DOI：10.1016/s0040-4020(99)00334-8

  日期：1999.5

  Enantioselective alkylation of chiral amide enolates derived From L-prolinol with beta-branched chiral iodides afforded good yields of hydroxy amide adducts. which were elaborated in four steps to give C-carboxyalkyl dipeptide inhibitors of stromelysin-1 (MMP-3). (C) 1999 Elsevier Science Ltd. All rights reserved.