4-methyl cycloheptanol | 90200-61-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methyl cycloheptanol
• 英文别名: optically inactive 4-hydroxy-1-methyl-cycloheptane；Opt.-inakt. 4-Hydroxy-1-methyl-cycloheptan；4-Methylcycloheptan-1-ol
• CAS: 90200-61-6
• 化学式: C₈H₁₆O
• 分子量: 128.214
• InChiKey: GNOXBYBSCDZVMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  197.67°C (rough estimate)
• 密度：
  0.9134

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyl cycloheptanol 在 三溴化磷 、 苯 作用下， 生成 1-bromo-4-methyl-cycloheptane
  参考文献：
  名称：

  BLICKE; JOHNSON, Journal of the American Pharmaceutical Association (1961), 1956, vol. 45, # 7, p. 443 - 445

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-环己基甲胺 在 溶剂黄146 、 sodium nitrite 作用下， 生成 4-methyl cycloheptanol
  参考文献：
  名称：

  Qudrat-i-Khuda; Ghosh, Journal of the Indian Chemical Society, 1940, vol. 17, p. 19,24

  摘要：

  DOI：

文献信息

• HEPATITIS B ANTIVIRAL AGENTS
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20170253609A1

  公开（公告）日：2017-09-07

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R  (I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了以下式(I)的化合物，或其药学上可接受的盐、酯或前药： X-A-Y-L-R  (I) 这些化合物抑制由乙型肝炎病毒（HBV）编码的蛋白质或干扰HBV生命周期的功能，并且还可用作抗病毒剂。本发明还涉及包含上述化合物的药物组合物，用于治疗患有HBV感染的受试者。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。
• [EN] SYNTHESIS OF SUBSTITUTED CYCLOPENTADIENE COMPOUNDS AND METALLOCENES<br/>[FR] SYNTHÈSE DE COMPOSÉS DE CYCLOPENTADIÈNE SUBSTITUÉS ET DE MÉTALLOCÈNES
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2020068420A1

  公开（公告）日：2020-04-02

  A method of synthesizing a substituted cyclopentadiene compound. The synthesis comprises a step of cyclizing, in the presence of a phosphorous pentoxide/methanesulfonic acid reagent, an alpha,beta-unsaturated carboxylic acid, cycloalkyl ester compound to make a substituted cyclopentenone compound, and converting the substituted cyclopentenone compound to the substituted cyclopentadiene compound. Also, a method of synthesizing a substituted metallocene compound comprising a metal-(substituted cyclopentadienyl ligand) complex, wherein the substituted cyclopentadienyl ligand is made from the substituted cyclopentadiene compound. A metal-(substituted cyclopentadienyl ligand) complex and substituted metallocene compound made by the method and a substituted metallocene catalyst made therefrom.

  一种合成取代环戊二烯化合物的方法。该合成包括在磷五氧化三磷/甲磺酸试剂存在下，通过环化步骤将α，β-不饱和羧酸，环烷基酯化合物环化为取代环戊酮化合物，并将取代环戊酮化合物转化为取代环戊二烯化合物。此外，还包括一种合成含金属-(取代环戊二烯基配体)复合物的取代茂金属化合物的方法，其中取代环戊二烯基配体是由取代环戊二烯化合物制备的。由该方法制备的金属-(取代环戊二烯基配体)复合物和取代茂金属化合物，以及由此制备的取代茂金属催化剂。
• [EN] SYNTHESIS OF CYCLOPENTENONES<br/>[FR] SYNTHÈSE DE CYCLOPENTÉNONES
  申请人：DOW GLOBAL TECHNOLOGIES LLC

  公开号：WO2020068419A1

  公开（公告）日：2020-04-02

  A method comprising synthesizing a substituted cyclopentenone compound via reaction of a substituted cycloalkyl acrylate ester in the presence of phosphorous pentoxide/methanesulfonic acid reagent to make the substituted cyclopentenone compound.

  一种方法包括在存在磷酸五氧化磷/甲磺酸试剂的情况下，通过对取代的环烷基丙烯酸酯进行反应合成取代的环戊烯酮化合物，以制备所述的取代的环戊烯酮化合物。
• PAI-1 INHIBITOR
  申请人：Yamaguchi Youichi

  公开号：US20090312315A1

  公开（公告）日：2009-12-17

  The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R 1 represents a C 6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents —N—C(═O)—CO 2 H or the like; when m is 1, G represents an oxygen atom or the like; R 2 represents a C 6-10 aryl group which may be substituted or the like; E represents the following formula (II) wherein one of R 31 , R 32 , R 33 and R 34 represents the formula R 1 -T-, each of the other three independently represents a hydrogen atom or the like, and R 35 represents the formula —X—Y′, a hydrogen atom or the like; X represents —CH 2 — or the like; Y′ represents a carboxy group or the like; M represents a single bond or the like.

  以下公式（I）表示的化合物及类似化合物具有PAI-1抑制活性；其中：R1代表可能被取代的C6-10芳基或类似基团；T代表单键或类似键；m代表0或1；当m为0时，G代表—N—C(═O)—CO2H或类似基团；当m为1时，G代表氧原子或类似基团；R2代表可能被取代的C6-10芳基或类似基团；E代表以下公式（II），其中R31、R32、R33和R34中的一个代表公式R1-T-，其余三个分别独立地代表氢原子或类似基团，R35代表公式—X—Y′，氢原子或类似基团；X代表—CH2—或类似基团；Y′代表羧基或类似基团；M代表单键或类似键。
• Extractive distillation of hydrocarbons employing solvent mixture
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0399193A2

  公开（公告）日：1990-11-28

  An extractive distillation process for separating at least one cycloalkane from at least one close-boiling alkane employs as solvent a mixture of (a) at least one saturated C5-C9 alcohol (preferably cyclohexanol) and (b) at least one glycol compound (preferably tetraethylene glycol).

  一种从至少一种沸点较低的烷烃中分离出至少一种环烷的萃取蒸馏工艺，采用(a)至少一种饱和 C5-C9 醇（最好是环己醇）和(b)至少一种乙二醇化合物（最好是四甘醇）的混合物作为溶剂。