(S)-dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate | 1291080-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate
• 英文别名: dimethyl (2S)-1-benzyl-2-phenyl-2,4-dihydroquinoline-3,3-dicarboxylate
• CAS: 1291080-52-8
• 化学式: C₂₆H₂₅NO₄
• 分子量: 415.489
• InChiKey: ZIQFMWBACHVHGQ-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(dibenzylamino)benzaldehyde 在 哌啶 、 (S)-6,6'-dimethyl-3,3'-bis(2,4-bistrifluoromethylphenyl)-1,1'-biphenyl-2,2'-yl phosphate 、 溶剂黄146 作用下， 以 甲苯 、 苯 为溶剂， 反应 41.5h， 生成 (S)-dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate
  参考文献：
  名称：

  Selective Activation of Enantiotopic C(sp³)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives

  摘要：

  Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).

  DOI：

  10.1021/ja2014955

文献信息

• Selective Activation of Enantiotopic C(sp³)−Hydrogen by Means of Chiral Phosphoric Acid: Asymmetric Synthesis of Tetrahydroquinoline Derivatives
  作者：Keiji Mori、Kensuke Ehara、Kazuki Kurihara、Takahiko Akiyama

  DOI：10.1021/ja2014955

  日期：2011.4.27

  Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).