yadanzioside F | 95258-11-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: yadanzioside F
• 英文别名: methyl (1R,2S,3R,6R,8S,9S,13S,14R,15R,16S,17S)-3-acetyloxy-15,16-dihydroxy-9,13-dimethyl-4,10-dioxo-11-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-11-ene-17-carboxylate
• CAS: 95258-11-0
• 化学式: C₂₉H₃₈O₁₆
• 分子量: 642.611
• InChiKey: BYBDRFPMKPUWDZ-NBVZOQEMSA-N

物化性质

• 沸点：
  878.7±65.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  45
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  245
• 氢给体数：
  6
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  yadanzioside F 在 β-glucosidase 作用下， 生成 Bruceine B
  参考文献：
  名称：

  New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.

  摘要：

  从鸦胆子种子中分离出了八种新的抗白血病类槲皮苷，即yadanziosides A-H（1-8），并通过化学转化和光谱分析确定了它们的结构。

  DOI：

  10.1248/cpb.32.4702

文献信息

• New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.
  作者：Toshiro Sakaki、Shin Yoshimura、Masami Ishibashi、Takahiko Tsuyuki、Takeyoshi Takahashi、Tadashi Honda、Toshihiro Nakanishi

  DOI：10.1248/cpb.32.4702

  日期：——

  Eight new antileukemic quassinoid glycosides, yadanziosides A-H (1-8) were isolated from seeds of Brucea javanica and their structures were determined by chemical transformation and spectral analysis.

  从鸦胆子种子中分离出了八种新的抗白血病类槲皮苷，即yadanziosides A-H（1-8），并通过化学转化和光谱分析确定了它们的结构。
• Constituents of Seeds of<i>Brucea javanica</i>. Structures of New Bitter Principles, Yadanziolides A, B, C, Yadanziosides F, I, J, and L.
  作者：Shin Yoshimura、Toshiro Sakaki、Masami Ishibashi、Takahiko Tsuyuki、Takeyoshi Takahashi、Tadashi Honda

  DOI：10.1246/bcsj.58.2673

  日期：1985.9

  Three new quassinoids and four new quassinoid glycosides were isolated from water-soluble fraction of methanol extract of seeds of Brucea javanica (L.) Merr, known as “Ya-dan-zi” in Chinese folklore and their structures were determined by spectral and chemical means. Yadanziosides F, I, J, and L were demonstrated to have antileukemic activity.

  从中国民间传说中的 "丫旦子"（Brucea javanica (L.) Merr）种子甲醇提取物的水溶性部分中分离出3种新的槲皮素和4种新的槲皮素苷，并通过光谱和化学方法确定了它们的结构。结果表明，雅丹子苷 F、I、J 和 L 具有抗白血病活性。