7-(methoxymethoxy)-3H-isobenzofuran-1-one | 344287-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 7-(methoxymethoxy)-3H-isobenzofuran-1-one
• 英文别名: 7-(methoxymethoxy)-3H-2-benzofuran-1-one
• CAS: 344287-41-8
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: AIEBMIXEHMRRFK-UHFFFAOYSA-N

物化性质

• 熔点：
  78 °C(Solvent: Chloroform ; Hexane)
• 沸点：
  388.9±42.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(methoxymethoxy)-3H-isobenzofuran-1-one 在 potassium carbonate 作用下， 以 四氢呋喃 、 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.17h， 生成 (5R)-3-{6-[(3,3-dimethyl-1,3-dihydro-2-benzofuran-4-yl)oxy]-3-pyridinyl}-5-ethyl-5-methyl-2,4-imidazolidinedione
  参考文献：
  名称：

  HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

  摘要：

  该发明提供了化合物的公式(I)：所述化合物是Kv3通道的抑制剂，可用于预防或治疗相关疾病。

  公开号：

  US20130267510A1
• 作为产物：
  描述：

  3-羟基苯甲醇 在 正丁基锂 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 、 苯 为溶剂， 反应 7.0h， 生成 7-(methoxymethoxy)-3H-isobenzofuran-1-one
  参考文献：
  名称：

  Studies towards the total synthesis of mumbaistatin: synthesis of highly substituted benzophenone and anthraquinone building blocks

  摘要：

  Model compounds and building blocks for a planned total synthesis of the highly potent glucose-6-phosphate (G6P) translocase inhibitor mumbaistatin (1) and structural analogs were elaborated: compound 1 represents a lead structure in the development of potential new antidiabetic drugs. With the model substrate 20 it was demonstrated that highly functionalized, tetra-ortho-substituted benzophenones can be prepared by nucleophilic addition of an aryllithium-building block to a benzaldehyde followed by oxidation. For compound 37, a potential precursor of the anthraquinone part of mumbaistatin, various approaches via aryne/phthalide annulations were developed and evaluated. The required functionalized arenes were prepared exploiting, among others, regioselective bromination and ortho-lithiation reactions. Coupling reactions of the anthracene-carbaldehyde 44 derived from 37 with various metalated arenes proved to be unexpectedly difficult and failed so far. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)00427-7

文献信息

• [EN] HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS<br/>[FR] DÉRIVÉS D'HYDANTOÏNE UTILES EN TANT QU'INHIBITEURS DE KV3
  申请人：AUTIFONY THERAPEUTICS LTD

  公开号：WO2012076877A1

  公开（公告）日：2012-06-14

  The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

  该发明提供了化合物的公式(I)：所述化合物是Kv3通道的抑制剂，可用于预防或治疗相关疾病。
• Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
  申请人：Chao J. Hannguang

  公开号：US20050267119A1

  公开（公告）日：2005-12-01

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是人类P2Y1受体的选择性抑制剂。本发明还提供了各种相应的制药组合物和调节P2Y1受体活性的治疗疾病的方法。
• UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
  申请人：Chao Hannguang J.

  公开号：US20080280905A1

  公开（公告）日：2008-11-13

  The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y 1 receptor activity.

  本发明提供了新型吡啶基或苯基脲及其类似物，它们是选择性的人类P2Y1受体抑制剂。本发明还提供了各种该类药物组成物和调节P2Y1受体活性以治疗对其反应的疾病的方法。
• Hydantoin derivatives useful as Kv3 inhibitors
  申请人：Alvaro Giuseppe

  公开号：US09346790B2

  公开（公告）日：2016-05-24

  The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

  本发明提供了式(I)的化合物：所述化合物是Kv3通道的抑制剂，用于预防或治疗相关疾病。
• Arene-metal complex in organic synthesis: directed regioselective lithiation of (.pi.-substituted benzene)chromium tricarbonyl complexes
  作者：Motokazu Uemura、Naomi Nishikawa、Kazuhiko Take、Masato Ohnishi、Ken Hirotsu、Taiichi Higuchi、Yuji Hayashi

  DOI：10.1021/jo00162a010

  日期：1983.7