9-decynoic acid chloride | 100131-19-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 9-decynoic acid chloride
• 英文别名: dec-9-ynoyl chloride；Dec-9-inoylchlorid
• CAS: 100131-19-9
• 化学式: C₁₀H₁₅ClO
• 分子量: 186.681
• InChiKey: DBUXKHVFDFZDCB-UHFFFAOYSA-N

物化性质

• 沸点：
  243.0±23.0 °C(Predicted)
• 密度：
  1.004±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-decynoic acid chloride 在 lithium hydroxide 、 sodium tetrahydroborate 、 copper(l) iodide 、 四溴化碳 、 氢气 、 nickel diacetate 、 potassium carbonate 、 三苯基膦 、 sodium iodide 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 25.5h， 生成 17-hydroxy-(9Z,12Z,15Z)-octadecatrienoic acid
  参考文献：
  名称：

  Volicitin 的简单正式合成

  摘要：

  摘要 简明扼要地合成了volicitin。该合成基于炔烃和炔丙基卤化物的重复化学选择性铜盐交叉偶联反应。

  DOI：

  10.1080/00397910008087419
• 作为产物：
  描述：

  9-癸炔-1-醇 在 sodium tungstate 、 草酰氯 、 双氧水 、 三辛基甲基硫酸铵 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 生成 9-decynoic acid chloride
  参考文献：
  名称：

  Volicitin 的简单正式合成

  摘要：

  摘要 简明扼要地合成了volicitin。该合成基于炔烃和炔丙基卤化物的重复化学选择性铜盐交叉偶联反应。

  DOI：

  10.1080/00397910008087419

文献信息

• Discovery of a Potent, Selective, and Efficacious Class of Reversible α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as Analgesics
  作者：Dale L. Boger、Hiroshi Miyauchi、Wu Du、Christophe Hardouin、Robert A. Fecik、Heng Cheng、Inkyu Hwang、Michael P. Hedrick、Donmienne Leung、Orlando Acevedo、Cristiano R. W. Guimarães、William L. Jorgensen、Benjamin F. Cravatt

  DOI：10.1021/jm049614v

  日期：2005.3.1

  Herein we report the discovery of a potent, selective, and efficacious class of reversible FAAH inhibitors that produce analgesia in animal models validating a new therapeutic target for pain intervention. Key to the useful inhibitor discovery was the routine implementation of a proteomics-wide selectivity screen against the serine hydrolase superfamily ensuring selectivity for FAAH coupled with systematic

  脂肪酸酰胺水解酶 (FAAH) 在其作用部位降解神经调节脂肪酸酰胺，包括 anandamide（内源性大麻素激动剂）和油酰胺（睡眠诱导脂质），并密切参与其调节。在这里，我们报告了在动物模型中发现了一种有效的、选择性的和有效的可逆 FAAH 抑制剂，它们可以产生镇痛作用，从而验证了疼痛干预的新治疗靶点。发现有用抑制剂的关键是常规实施针对丝氨酸水解酶超家族的蛋白质组学选择性筛选，确保对 FAAH 的选择性，并结合候选抑制剂的系统体内检查。
• The Frontier Mountain meteorite trap (Antarctica)
  作者：Luigi FOLCO、Alessandro CAPRA、Massimo CHIAPPINI、Màssimo FREZZOTTI、Marcello MELLINI、Ignazio Ezio TABACCO

  DOI：10.1111/j.1945-5100.2002.tb01105.x

  日期：2002.2

  Abstract— The Frontier Mountain blue ice field is an important Antarctic meteorite trap which has yielded 472 meteorite specimens since its discovery in 1984. Remote sensing analyses and field campaigns from 1993 to 1999 have furnished new glaciological data on ice flow, ice thickness, bedrock topography, ice ablation and surface mass transport by wind, along with detailed descriptions of the field situation at the trap. This solid set of data combined with an updated meteorite distribution map and terrestrial ages available from literature allows us to better describe the nature of the concentration mechanism. In particular, we observe that the meteorite trap forms in a blue ice field (1) located upstream of an absolute and a shallow sub‐ice barriers; (2) characterized by compressive ice flow with horizontal velocities decreasing from 100 to <10 cm/year on approaching the obstacle; (3) undergoing mean ablation rates of 6.5 cm/year; (4) nourished by a limited snow accumulation zone extending ˜20 km upstream of the blue ice area. We also draw the following conclusions: (1) the origin of the meteorite trap can be explained according to the present‐day glaciological situation; (2) the meteorite concentration develops according to the general principles of the “ice flow model”; (3) the accumulation model can be described as “stagnant ice or slow‐moving ice against an absolute and submerged barriers”, according to the descriptive schemes present in literature; (4) the Frontier Mountain ice field is an effective trap for meteorites weighing more than ˜200 g; for smaller masses, the combination of wind and glacial drift may remove meteorites in less than a few tens of thousands of years; (5) although the activation age of the Frontier Mountain trap is not yet constrained, we infer that one of the most important findsites may be as old as 50 ka, predating the last glacial maximum.
• PROTEIN KINASE C MODULATORS WITH ANTI-INFLAMMATORY AND ANTIVIRAL ACTIVITY
  申请人：ALDER RESEARCH CENTER LIMITED PARTNERSHIP

  公开号：EP0553107A1

  公开（公告）日：1993-08-04
• US5643948A
  申请人：——

  公开号：US5643948A

  公开（公告）日：1997-07-01
• US5716968A
  申请人：——

  公开号：US5716968A

  公开（公告）日：1998-02-10