环戊烷羰基氟 | 10412-82-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 中文名称: 环戊烷羰基氟
• 英文名称: cyclopentanecarbonyl fluoride
• 英文别名: Cyclopentan-carbonsaeurefluorid；Cyclopentylcarbonylfluorid
• CAS: 10412-82-5
• 化学式: C₆H₉FO
• 分子量: 116.135
• InChiKey: SHNMAZAKJODKGR-UHFFFAOYSA-N

物化性质

• 沸点：
  58-60 °C(Press: 80 Torr)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  环戊烷羰基氟 生成 环戊烷羧酰胺
  参考文献：
  名称：

  Cyclopropanecarboxylic acid fluoride. Improved synthesis

  摘要：

  DOI：

  10.1021/jo01268a098
• 作为产物：
  描述：

  环戊酸 在 吡啶 、 三聚氟氰 作用下， 以 乙腈 为溶剂， 生成 环戊烷羰基氟
  参考文献：
  名称：

  合成方法和反应；IV.1 用氰尿酸氟化羧酸

  摘要：

  DOI：

  10.1055/s-1973-22238

文献信息

• Friedel–Crafts reactions of acyl trifluoromethanesulfonates and cyclic acylsulfonium cations generated from acyl fluorides
  作者：K.V. Raghavendra Rao、Yannick Vallée

  DOI：10.1016/j.tet.2016.06.029

  日期：2016.7

  Reactive acyl trifluoromethanesulfonates are formed from the reaction of acyl fluorides with trimethylsilyl trifluoromethanesulfonate (TMSOTf). These electrophiles undergo Friedel–Crafts reactions with electron-rich aromatics at room temperature. When a sulfur atom is present at their γ position, their cyclization to acylsulfonium cations is observed and is followed by a rearrangement leading to benzothiepinones

  反应性酰基三氟甲磺酸盐是由酰基氟与三甲基甲硅烷基三氟甲磺酸盐（TMSOTf）反应形成的。这些亲电试剂在室温下与富电子芳族化合物发生Friedel-Crafts反应。当硫原子存在于其γ位置时，观察到它们被环化为酰基ls阳离子，随后发生重排，生成苯并噻吩酮（或二苯并[ b，e ]噻吩酮），产率为40-85％。
• Versatile Palladium-Catalyzed Approach to Acyl Fluorides and Carbonylations by Combining Visible Light- and Ligand-Driven Operations
  作者：Yi Liu、Cuihan Zhou、Meijing Jiang、Bruce A. Arndtsen

  DOI：10.1021/jacs.2c01951

  日期：2022.6.1

  We describe the development of a general palladium-catalyzed carbonylative method to synthesize acyl fluorides from aryl, heteroaryl, alkyl, and functionalized organic halides. Mechanistic analysis suggests that the reaction proceeds via the synergistic combination of visible light photoexcitation of Pd(0) to induce oxidative addition with a ligand-favored reductive elimination. These together create

  我们描述了从芳基、杂芳基、烷基和官能化有机卤化物合成酰基氟化物的一般钯催化羰基化方法的发展。机理分析表明，反应通过Pd(0) 的可见光光激发的协同组合进行，以诱导氧化加成和配体有利的还原消除。这些共同创造了一个单向催化循环，不受一氧化碳配位的经典效应的抑制。将酰氟的催化形成与其随后的亲核反应相结合，开辟了一种以前所未有的广度进行羰基化反应的方法，包括高度官能化的含羰基产物的组装。
• Treatment of laminitis with platelet aggregation inhibitors
  申请人：Dussler, Sabine

  公开号：EP2497475A1

  公开（公告）日：2012-09-12

  The present invention relates to the novel use of platelet aggregation inhibitors for the treatment and/or prevention of Laminitis in veterinary medicine. In particular the invention refers to the novel use of specific antiplatelet drugs for the treatment and/or prevention of Laminitis.

  本发明涉及在兽医学中使用血小板聚集抑制剂治疗和/或预防蹄叶炎的新方法。特别是，本发明涉及特定抗血小板药物在治疗和/或预防蹄叶炎方面的新用途。
• Polymer coatings
  申请人：Illumina, Inc.

  公开号：US10954561B2

  公开（公告）日：2021-03-23

  The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein.

  本公开涉及共价连接到基底表面的聚合物涂层和聚合物涂层的制备，例如聚(N-(5-叠氮乙酰胺戊基)丙烯酰胺-共丙烯酰胺)(PAZAM)，用于形成和操作基底，例如分子阵列和流动池。本公开还涉及通过使用涂有共价连接聚合物（如 PAZAM）的珠子制备基底表面的方法，以及确定附着在本文所述基底表面的多核苷酸的核苷酸序列的方法。
• [Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent:  Application toward One-Flask Transformations of Carboxylic Acids to Amides
  作者：Jonathan M. White、Ashok Rao Tunoori、Brandon J. Turunen、Gunda I. Georg

  DOI：10.1021/jo035658k

  日期：2004.4.1

  The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.