2-(Dimethylamino)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(Dimethylamino)-4,7,7-trimethylbicyclo[2.2.1]heptan-3-ol
• 英文别名: 3-(dimethylamino)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol
• 化学式: C₁₂H₂₃NO
• 分子量: 197.32
• InChiKey: ZDEYHASQASZDRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION
  申请人：WAGNER Holger

  公开号：US20120046304A1

  公开（公告）日：2012-02-23

  The present invention relates to compounds defined by formula I wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及由公式I定义的化合物 其中变量R1-R8定义如说明书中所述，具有宝贵的药理活性。特别是，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适合用于治疗和预防可以通过抑制该酶而影响的疾病。
• Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation
  申请人：Wagner Holger

  公开号：US20130053404A1

  公开（公告）日：2013-02-28

  The present invention relates to compounds defined by formula I wherein the variables R 1 -R 8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及由式I定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理活性。特别地，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防受该酶抑制影响的疾病。
• [EN] TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION<br/>[FR] DÉRIVÉS DE PYRIDINES TRICYCLIQUES, MÉDICAMENTS CONTENANT CES COMPOSÉS, LEUR UTILISATION ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009109549A1

  公开（公告）日：2009-09-11

  Compounds of formula (I) wherein the groups R1 to R8 have the meanings indicated in the description, the tautomers.the stereoisomers.the mixtures thereof and the salts thereof have valuable pharmacological properties.which make them useful for the treatment of cardiovascular and related disorders.

  式（I）中的化合物，其中基团R1至R8具有描述中所指的含义，其互变异构体、立体异构体、混合物及其盐具有有价值的药理特性，使它们在治疗心血管及相关疾病方面具有用途。
• [EN] TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION<br/>[FR] DÉRIVÉS DE PYRIDINE TRICYCLIQUE, MÉDICAMENTS CONTENANT DE TELS COMPOSÉS, LEUR UTILISATION ET L'UN DE LEURS PROCÉDÉS DE SYNTHÈSE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012110599A1

  公开（公告）日：2012-08-23

  The present invention relates to compounds defined by formula (I), wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.

  本发明涉及由式（I）定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理活性。特别地，这些化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防受该酶抑制影响的疾病。
• Novel imidazole derivatives, production method thereof and use thereof
  申请人：——

  公开号：US20040033935A1

  公开（公告）日：2004-02-19

  The present invention provides a compound having a steroid C 17,20 -lyase-inhibitory activity and useful for the therapy and prophylaxis of tumor such as prostatism, breast cancer and the like, and a method for efficiently separating an optically active compound of this compound from a mixture of optical isomers thereof, a compound of the formula: 1 wherein each symbol is as defined in the specification, a salt thereof or a prodrug thereof, and a method for obtaining an optically active compound by optically resolving a mixture of optical isomers by the use of a resolving agent such as tartranilic acid and the like.

  本发明提供一种具有类固醇C17,20-裂解酶抑制活性的化合物，用于治疗和预防前列腺癌、乳腺癌等肿瘤，以及一种有效地从其光学异构体混合物中分离出该化合物的光学活性化合物的方法，该化合物的化学式为：1其中每个符号如规范中定义，其盐或前药，以及通过使用像酞氨酸等分离剂对光学异构体混合物进行光学分离来获得光学活性化合物的方法。