3-methoxyoctanal | 1035807-73-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methoxyoctanal
• 英文别名: 3-Methoxyoctanal
• CAS: 1035807-73-8
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: ICLPDWKIWBEUKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxyoctanal 在 2,6-二甲基吡啶 、 氧气 、 臭氧 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 (4R,6S,8S)-6-(tert-butyldimethylsilyloxy)-8-methoxytridec-1-en-4-ol
  参考文献：
  名称：

  Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

  摘要：

  The preparation preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to alpha-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.011
• 作为产物：
  描述：

  4-methoxy-1-nonene 在 2,6-二甲基吡啶 、 四氧化锇 、 sodium periodate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以48 %的产率得到3-methoxyoctanal
  参考文献：
  名称：

  On the role of β-silyloxy- and β-alkoxyaldehyde protecting groups in Mukaiyama aldol 1,3-diastereocontrol

  摘要：

  DOI：

  10.1016/j.tetlet.2022.154203

文献信息

• Thieme Chemistry Journal Awardees - Where Are They Now? Aldol Synthesis by anti-Markovnikov Hydration of Propargyloxy Substrates: Feasibility, Stereospecifity, and Reiterative Alkynylation-Hydration
  作者：Lukas Hintermann、Thomas Kribber、Aurélie Labonne、Eva Paciok

  DOI：10.1055/s-0029-1217734

  日期：2009.9

  Aldol derivatives have been synthesized by redox-neutral catalytic anti-Markovnikov hydration of propargyloxy substrates. A reiterative sequence of aldehyde alkynylation and alkyne hydration leads to 1,3-polyol derivatives.

  通过氧化还原中性催化的反马克诺夫水合反应合成了醛醇衍生物。醛的炔基化和炔烃水合的重复序列导致了1,3-多醇衍生物的形成。
• COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION
  申请人：Ishida Kenya

  公开号：US20110117147A1

  公开（公告）日：2011-05-19

  The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from 1-menthol, 1-isopulegol, 3-(1-menthoxy)propan-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
• US8632792B2
  申请人：——

  公开号：US8632792B2

  公开（公告）日：2014-01-21
• [EN] COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION<br/>[FR] COMPOSITION D'AGENT DE SENSATION DE FRAÎCHEUR ET COMPOSITION D'AGENT DE STIMULATION SENSORIELLE
  申请人：TAKASAGO PERFUMERY CO LTD

  公开号：WO2009123355A2

  公开（公告）日：2009-10-08

  The invention relates to a cooling sensation agent composition with a prolonged cool sensation effect comprising at least one compound selected from Formula (1) wherein each of A and B is a hydrogen atom or a hydrocarbon group which may have one or more substituents, in which A and B are not hydrogen atoms simultaneously, and the total number of carbon atoms in A and B is in the range of 6 to 18; and Formulae (2) to (4) wherein R1, R2, and R3 each represent a residue of an alcohol selected from l-menthol, l-isopulegol, 3-(l-menthoxy)propan-1,2-diol, 2-(l-menthoxy)ethan-1-ol, 3-(l-menthoxy)propan-1-ol, 2-methyl-3-(l-menthoxy)propan-1,2-diol and para-menthan-3,8-diol), and R4 represents a residue of a branched or straight-chain, cyclic or linear, or saturated or unsaturated alcohol having 6 to 18 carbon atoms that may have one or more aromatic rings that may have a condensed ring and substituent groups such as hydroxyl and ether groups; and R6 represents a hydrocarbon group having 11 to 19 carbon atoms that may be branched and contain one or more unsaturated bonds. The invention also relates to a sensory stimulation agent composition comprising the cooling sensation agent composition; a flavor or fragrance composition, a beverage or food product, a perfume or cosmetic product, a toiletry product, a daily utensil product or grocery, a fiber, a fiber product, a cloth or a medicine comprising the cooling sensation agent composition or the sensory stimulation agent composition; a production method thereof; a cooling processing method of a fiber, fiber product or a cloth, comprising compounding the cooling sensation agent composition or the sensory stimulation agent composition; and new compounds.
• Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
  作者：J. Alberto Marco、Jorge García-Pla、Miguel Carda、Juan Murga、Eva Falomir、Chiara Trigili、Sara Notararigo、J. Fernando Díaz、Isabel Barasoain

  DOI：10.1016/j.ejmech.2011.02.011

  日期：2011.5

  The preparation preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to alpha-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities. (C) 2011 Elsevier Masson SAS. All rights reserved.