(2S,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2S,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-(2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₃₆H₆₂O₈
• 分子量: 622.9
• InChiKey: CKUVNOCSBYYHIS-ZUHZXIPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  140
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• SAPONIN NANO MICELLE, PREPARING METHOD, APPLICATION AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：FUJIAN SOUTH PHARMACEUTICAL CO. LTD.

  公开号：US20150297727A1

  公开（公告）日：2015-10-22

  A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R 1 and R 2 are independently —H or a hydrophilic group, R 3 is —H or —OH, R 4 is a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions.

  本发明公开了一种皂苷纳米胶束，其制备方法、应用及制药组合物。该皂苷纳米胶束包含式1所代表的一个或多个皂苷，其中R1和R2独立地为—H或亲水基团，R3为—H或—OH，R4为亲脂基团。该皂苷纳米胶束的制备方法是将皂苷与能溶解皂苷的有机溶剂混合，然后去除有机溶剂。皂苷胶束作为药物成分的传递介质，可以替代传统的药物载体，如药物溶解剂或聚合物胶束，具有高安全性和重要意义。制药成分可以延长药物在血液中的循环时间和生物半衰期，增加药物在病变部位的积累，并减少不良反应。
• SAPONIN NANO-MICELLE AND PREPARATION METHOD, USE AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：Fujian South Pharmaceutical Co., Ltd

  公开号：EP2815746A1

  公开（公告）日：2014-12-24

  A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R1 and R2 are independently -H or a hydrophilic group, R3 is -H or -OH, R4 is a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The positive micelle in the saponin nano micelle can be used as drug-loading micelle of water-indissolvable lipid-soluble pharmaceutical ingredients, which has a stronger drug-loading capacity and higher biological compatibility; the reverse micelle in the saponin nano micelle can be used as a solubilizer of water-soluble drugs or water-soluble ingredients, as well as drug-loading micelle of water-soluble drugs. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions.

  本发明公开了一种皂苷纳米胶束及其制备方法、应用和药物组合物。皂素纳米胶束由一种或多种皂素组成，皂素纳米胶束由式 1 表示，其中，R1 和 R2 独立地为-H 或亲水基团，R3 为-H 或-OH，R4 为亲脂基团。皂素纳米胶束的制备方法是将皂素与能溶解皂素的有机溶剂混合，然后除去有机溶剂。皂苷纳米胶束中的正胶束可作为水溶性脂溶性药物成分的载药胶束，载药能力更强，生物相容性更高；皂苷纳米胶束中的反胶束可作为水溶性药物或水溶性成分的增溶剂，也可作为水溶性药物的载药胶束。皂苷胶束作为药物成分的输送介质，可替代药用增溶剂或聚合物胶束等传统药物载体，安全性高，意义重大。该药物成分可延长药物在血液中的循环时间和生物半衰期，增加药物在病灶中的蓄积，减少不良反应。
• A Novel Blank Liposome with Ginsenoside Rg3 or its Analog as Membrane Materials and Preparations and Uses Thereof
  申请人：Shanghai Ginsome Pharmatech Co., Ltd.

  公开号：US20200369714A1

  公开（公告）日：2020-11-26

  The present invention provides a blank liposome with ginsenoside Rg3 or its anaglog as the membrane material, preparations and uses thereof. The disclosed blank liposome has a membrane comprising a lipid and a ginsenoside analog of Formula I, presenting remarkable advantages in film formation, encapsulation efficiency, targeted drug delivery, blood circulation time, stability, safety and homogeneity. It can also be used to load active substances of drugs and cosmetics, biological agents, polynucleotides or oligonucleotides, and the preparation process is convenient.
• US9421269B2
  申请人：——

  公开号：US9421269B2

  公开（公告）日：2016-08-23