7-(2-氨基乙基硫基)-1-环丙基-6-氟-4-氧代喹啉-3-羧酸 | 128751-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-(2-氨基乙基硫基)-1-环丙基-6-氟-4-氧代喹啉-3-羧酸
• 英文名称: 7-(2-Aminoethylthio)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 7-(2-aminoethylsulfanyl)-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
• CAS: 128751-33-7
• 化学式: C₁₅H₁₅FN₂O₃S
• 分子量: 322.4
• InChiKey: DJRCXRJWNQKZPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-(2-氨基乙基硫基)-1-环丙基-6-氟-4-氧代喹啉-3-羧酸 、 乙酸酐 、 吡啶 生成 7-(2-acetamidoethylsulfanyl)-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  YOSHIDA, TOSHIHIKO;YAMAMOTO, YOICHI;YAGI, NORIYUKI;YASUDA, SHINGO;KATOH, +, YAKUGAKU DZASSI, 110,(1990) N, S. 258-267

  摘要：

  DOI：
• 作为产物：
  描述：

  1-环丙基-6,7-二氟-1,4-二氢-4-氧喹啉-3-羧酸 、 巯基乙胺 、 potassium carbonate 生成 7-(2-氨基乙基硫基)-1-环丙基-6-氟-4-氧代喹啉-3-羧酸
  参考文献：
  名称：

  YOSHIDA, TOSHIHIKO;YAMAMOTO, YOICHI;YAGI, NORIYUKI;YASUDA, SHINGO;KATOH, +, YAKUGAKU DZASSI, 110,(1990) N, S. 258-267

  摘要：

  DOI：

文献信息

• YOSHIDA, TOSHIHIKO;YAMAMOTO, YOICHI;YAGI, NORIYUKI;YASUDA, SHINGO;KATOH, +, YAKUGAKU DZASSI, 110,(1990) N, S. 258-267
  作者：YOSHIDA, TOSHIHIKO、YAMAMOTO, YOICHI、YAGI, NORIYUKI、YASUDA, SHINGO、KATOH, +

  DOI：——

  日期：——
• Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest
  申请人：Peng Jin

  公开号：US20090306035A1

  公开（公告）日：2009-12-10

  Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic formulations comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.