16-Oxo-16-phenacyloxyhexadecanoic acid | 443770-14-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 16-Oxo-16-phenacyloxyhexadecanoic acid
• 英文别名: 16-oxo-16-phenacyloxyhexadecanoic acid
• CAS: 443770-14-7
• 化学式: C₂₄H₃₆O₅
• 分子量: 404.547
• InChiKey: UHEUFNPYUAPAIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  29
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  16-Oxo-16-phenacyloxyhexadecanoic acid 在 咪唑 、 sodium hydride 、 苯硫酚 、 N,N-二异丙基乙胺 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成 15-{[4-(Trityl-amino)-butyl]-[3-(trityl-amino)-propyl]-carbamoyl}-pentadecanoic acid
  参考文献：
  名称：

  Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements

  摘要：

  Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenuilobine analogues were readily obtained by using Hda or its dichloride or succinic anhydride to bridge the polyamine moieties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00338-6
• 作为产物：
  描述：

  十六碳二酸 、 2-溴苯乙酮 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以65%的产率得到16-Oxo-16-phenacyloxyhexadecanoic acid
  参考文献：
  名称：

  Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements

  摘要：

  Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenuilobine analogues were readily obtained by using Hda or its dichloride or succinic anhydride to bridge the polyamine moieties. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00338-6

文献信息

• Simple syntheses of the polyamine alkaloid tenuilobine and analogues using selectively N-tritylated polyamines and dicarboxylic acids as bridging elements
  作者：Stratos Vassis、Ioannis Govaris、Katerina Voyagi、Petros Mamos、Dionissios Papaioannou

  DOI：10.1016/s0040-4039(02)00338-6

  日期：2002.4

  Selectively N-tritylated spermidine and spermine derivatives and the monophenacyl ester of 1,16-hexadecanedioic acid (Hda) were used to obtain the polyamine alkaloid tenuilobine and its fully reduced analogue. Other symmetric or side-chain-shortened tenuilobine analogues were readily obtained by using Hda or its dichloride or succinic anhydride to bridge the polyamine moieties. (C) 2002 Elsevier Science Ltd. All rights reserved.