1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-imidazolyl)-4-oxo-3-quinolinecarboxylic acid | 93242-60-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-imidazolyl)-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 1-Ethyl-6,8-difluoro-7-(4-methylimidazol-1-yl)-4-oxoquinoline-3-carboxylic acid
• CAS: 93242-60-5
• 化学式: C₁₆H₁₃F₂N₃O₃
• 分子量: 333.294
• InChiKey: FHRGQBHBRAUGIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  75.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-乙基-6,7,8-三氟-1,4-二氢-4-氧代喹啉-2-羧酸 生成 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-imidazolyl)-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  UNO, TOSHIO;TAKAMATSU, MASANORI;IUCHI, KOJI;TSUKAMOTO, GORO

  摘要：

  DOI：

文献信息

• Synthesis of antimicrobial agents. 1. Syntheses and antibacterial activities of 7-(azole substituted)quinolones
  作者：Toshio Uno、Masanori Takamatsu、Yoshimasa Inoue、Yoshihiro Kawahata、Koji Iuchi、Goro Tsukamoto

  DOI：10.1021/jm00395a001

  日期：1987.12

  Structure-activity relationship studies indicated that the antibacterial potency was better when the 6,8-substituents were fluorine atoms and the 7-substituent was either 1-imidazolyl, 20, or 4-methyl-1-imidazolyl, 25. From the results of studies on pharmacokinetic profile and toxicity, 20 and 25 were found to possess excellent antibacterial activities and to show high blood levels after oral administration

  制备了一系列6-氟-和6,8-二氟-7-（唑取代的）-1,4-二氢-4-氧代-3-喹啉羧酸。结构活性关系研究表明，当6,8-取代基是氟原子，而7-取代基是1-咪唑基20或4-甲基-1-咪唑基25时，抗菌效果更好。在药代动力学和毒性研究中，发现20和25具有出色的抗菌活性，并且对低毒性小鼠口服后显示出较高的血药浓度。
• 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4-oxoquinoline-3-carboxylic acid derivatives, process for preparing the same and anti-microbial compositions
  申请人：KANEBO, LTD.

  公开号：EP0115049A1

  公开（公告）日：1984-08-08

  1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4- oxoquinoline-3-carboxylic acid derivative of the formula: wherein R is hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and processes for preparing the same are disclosed. In form of pharmaceutical compositions they exhibit excellent anti-microbial activities and are useful as an anti-microbial agent for the treatment of infections diseases in warm-blood animals including human beings.

  式中的 1-乙基-6,8-二氟-1,4-二氢-7-(1-咪唑基)-4-氧代喹啉-3-羧酸衍生物： 式中 R 为氢原子或具有 1 至 3 个碳原子的烷基的衍生物及其制备方法均已公开。在药物组合物中，它们表现出优异的抗微生物活性，可作为抗微生物剂用于治疗包括人类在内的温血动物的感染性疾病。
• UNO, TOSHIO;TAKAMATSU, MASANORI;IUCHI, KOJI;TSUKAMOTO, GORO
  作者：UNO, TOSHIO、TAKAMATSU, MASANORI、IUCHI, KOJI、TSUKAMOTO, GORO

  DOI：——

  日期：——
• UNO, TOSHIO;TAKAMATSU, MASANORI;INOUE, YOSHIMASA;KAWAHATA, YOSHIHIRO;IUCH+, J. MED. CHEM., 30,(1987) N 12, 2163-2169
  作者：UNO, TOSHIO、TAKAMATSU, MASANORI、INOUE, YOSHIMASA、KAWAHATA, YOSHIHIRO、IUCH+

  DOI：——

  日期：——
• JPS60130587A
  申请人：——

  公开号：JPS60130587A

  公开（公告）日：1985-07-12