(S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl methyl carbonate | 1429033-48-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl methyl carbonate
• 英文别名: [(2S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl] methyl carbonate
• CAS: 1429033-48-6
• 化学式: C₁₃H₂₂O₆
• 分子量: 274.314
• InChiKey: NRTBXBYYSKJWPC-DCAQKATOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl methyl carbonate 在 2,6-二叔丁基-4-甲基苯酚 、 双(三甲基硅烷基)氨基钾 、 sodium hydride 、 碳酸氢钠 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 二氯甲烷 、 邻二氯苯 、 mineral oil 为溶剂， 反应 90.58h， 生成 allyl {(3aS,5S,5aR,9aS,9bS)-5-[(methoxycarbonyl)oxy]-2,2,5a,9-tetramethyl-3a,4,5,5a,6,7,9a,9b-octahydronaphtho[1,2-d][1,3]dioxol-8-yl} dicarbonate
  参考文献：
  名称：

  A Stereoconvergent Intramolecular Diels–Alder Cycloaddition Related to the Construction of the Decalin Core of neo-Clerodane Diterpenoids

  摘要：

  Several examples of a highly specific, stereoconvergent intramolecular Diels-Alder cycloaddition that led to the trans-decalin core of neo-clerodane diterpenoids are described. The relative configuration adjacent to the dienophile, which led to C4 of the decalin system, as well as the electron withdrawing effects of various substituents and conformational rigidity of the Diels-Alder precursors were explored.

  DOI：

  10.1021/jo400029u
• 作为产物：
  描述：

  (S)-1-[(4S,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl methyl carbonate 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以94%的产率得到(S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-methylbut-3-en-2-yl methyl carbonate
  参考文献：
  名称：

  A Stereoconvergent Intramolecular Diels–Alder Cycloaddition Related to the Construction of the Decalin Core of neo-Clerodane Diterpenoids

  摘要：

  Several examples of a highly specific, stereoconvergent intramolecular Diels-Alder cycloaddition that led to the trans-decalin core of neo-clerodane diterpenoids are described. The relative configuration adjacent to the dienophile, which led to C4 of the decalin system, as well as the electron withdrawing effects of various substituents and conformational rigidity of the Diels-Alder precursors were explored.

  DOI：

  10.1021/jo400029u

文献信息

• A Stereoconvergent Intramolecular Diels–Alder Cycloaddition Related to the Construction of the Decalin Core of <i>neo</i>-Clerodane Diterpenoids
  作者：Sean C. Butler、Craig J. Forsyth

  DOI：10.1021/jo400029u

  日期：2013.4.19

  Several examples of a highly specific, stereoconvergent intramolecular Diels-Alder cycloaddition that led to the trans-decalin core of neo-clerodane diterpenoids are described. The relative configuration adjacent to the dienophile, which led to C4 of the decalin system, as well as the electron withdrawing effects of various substituents and conformational rigidity of the Diels-Alder precursors were explored.