7-氯-4-肼基喹啉盐酸盐 | 786727-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-氯-4-肼基喹啉盐酸盐
• 英文名称: (7-chloroquinolin-4-yl)-hydrazine hydrochloride
• 英文别名: 7-Chloro-4-hydrazinoquinoline hydrochloride；(7-chloroquinolin-4-yl)hydrazine;hydrochloride
• CAS: 786727-08-0
• 化学式: C₉H₈ClN₃*ClH
• 分子量: 230.097
• InChiKey: IUWWSSGVZWPHMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-氯-4-肼基喹啉盐酸盐 在 盐酸 、 水 、 溶剂黄146 、 lithium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 生成 1-(7-氯喹啉-4-基)-5-(2,6-二甲氧基苯基)-1H-吡唑-3-羧酸
  参考文献：
  名称：

  [EN] PYRAZOLE COMPOUNDS SELECTIVE FOR NEUROTENSIN 2 RECEPTOR
  [FR] COMPOSÉS DE PYRAZOLE SÉLECTIFS VIS-À-VIS DU RÉCEPTEUR DE LA NEUROTENSINE DE SOUS-TYPE 2

  摘要：

  这项发明通常涉及发现对神经肽受体2（NTR2）具有选择性的吡唑化合物以及其用途。

  公开号：

  WO2015148465A1

文献信息

• Pyrazole-amides and sulfonamides as sodium channel modulators
  申请人：Atkinson N. Robert

  公开号：US20050020564A1

  公开（公告）日：2005-01-27

  Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.

  本发明的化合物调节哺乳动物中的PN3，并且在治疗哺乳动物的疼痛方面是有用的。
• Identification of 1-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1<i>H</i>-pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound
  作者：James B. Thomas、Angela M. Giddings、Robert W. Wiethe、Srinivas Olepu、Keith R. Warner、Philippe Sarret、Louis Gendron、Jean-Michel Longpre、Yanan Zhang、Scott P. Runyon、Brian P. Gilmour

  DOI：10.1021/jm5003843

  日期：2014.6.26

  Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. With the aim of identifying novel nonpeptide compounds selective for NTS2, we examined analogues of SR48692 (5a) using a FLIPR calcium assay in CHO cells stably expressing rat NTS2. This led to the discovery of the NTS2 selective nonpeptide compound 1-([1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid (NTRC-739, 7b) starting from the nonselective compound 5a.
• PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS
  申请人：ABBOTT LABORATORIES

  公开号：EP1620405A2

  公开（公告）日：2006-02-01
• PYRAZOLE COMPOUNDS SELECTIVE FOR NEUROTENSIN 2 RECEPTOR
  申请人：RESEARCH TRIANGLE INSTITUTE

  公开号：US20170174633A1

  公开（公告）日：2017-06-22

  This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.
• [EN] PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS<br/>[FR] PYRAZOLE-AMIDES ET SULFONAMIDES MODULATEURS DES CANAUX SODIQUES
  申请人：ABBOTT LAB

  公开号：WO2004099154A2

  公开（公告）日：2004-11-18

  Compounds of formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, heterocycle, heterocyclealkyl, heteroaryl, or heteroarylalkyl; R4 is formula (Ia), formula (Ib), formula (Ic), formula (Id), formula (Ie) or formula (If); or formula (II), or a pharmaceutically acceptable salt, amide, ester or prodrug thereof, wherein R14 is formula (III), formula (IV), formula (V), formula (VI), formula (VII), formula (VIII), formula (IX), formula (X), formula (XI), or formula (XII); modulate PN3 in mammals and are useful in treating pain in mammals.