7-氯-4-苯氧基喹啉 | 124495-03-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 7-氯-4-苯氧基喹啉
• 英文名称: 7-chloro-4-phenoxyquinoline
• 英文别名: 7-chloro-4-phenoxy-quinoline；7-Chlor-4-phenoxy-chinolin；4-Phenoxy-7-chlorchinolin
• CAS: 124495-03-0
• 化学式: C₁₅H₁₀ClNO
• 分子量: 255.703
• InChiKey: MCZMMMMRPAAMQX-UHFFFAOYSA-N

物化性质

• 熔点：
  204-206 °C
• 沸点：
  154.5-157 °C(Press: 0.2-0.3 Torr)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-氯-4-苯氧基喹啉 、 氨磷汀 以 various solvent(s) 为溶剂， 反应 6.0h， 以48%的产率得到S-< 2-(3-((7-chloro-4-quinolyl)amino)propyl)aminoethyl > phosphorothioate
  参考文献：
  名称：

  Synthesis of N-acridinyl and N-quinolinyl derivatives of radioprotective amino-thiols

  摘要：

  DOI：

  10.1016/s0040-4020(01)89522-3
• 作为产物：
  描述：

  4,7-二氯喹啉 、 苯酚 在 sodium hydroxide 作用下， 反应 7.0h， 以92%的产率得到7-氯-4-苯氧基喹啉
  参考文献：
  名称：

  Synthesis of N-acridinyl and N-quinolinyl derivatives of radioprotective amino-thiols

  摘要：

  DOI：

  10.1016/s0040-4020(01)89522-3

文献信息

• [EN] 4-AMINOQUINOLINE COMPOUNDS FOR THE TREATMENT OF ANGIOGENESIS<br/>[FR] COMPOSÉS DE 4-AMINOQUINOLINE POUR LE TRAITEMENT DE L'ANGIOGENÈSE
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2019173482A1

  公开（公告）日：2019-09-12

  Described herein is the use of 4-aminoquinoline compounds as inhibitors of angiogenesis, such as retinal pathological angiogensis. Also described herein are compositions and formulations comprising such compounds for the use in treatment of pathological angiogenesis.

  本文描述了4-氨基喹啉化合物作为抑制血管生成的用途，例如视网膜病理性血管生成。本文还描述了包含这些化合物的组合物和配方，用于治疗病理性血管生成。
• Lewis Acid-Catalyzed Generation of CC and CN Bonds on π-Deficient Heterocyclic Substrates
  作者：Matteo Staderini、Maria Laura Bolognesi、J. Carlos Menéndez

  DOI：10.1002/adsc.201400674

  日期：2015.1.12

  to the efficient and completely regioselective generation of aromatic CC and CN bonds. The method is simple, rapid, general and inexpensive, and can be performed without the use of dried solvents. Most of the synthetized compounds are new and in many cases the work‐up required only filtration. Furthermore, this is the first example of the use of a Lewis acid as a catalyst for heteroarylation, vinylation

  在催化量的三氯化铟的存在下，对一系列卤化的氮杂环和不同种类的亲核试剂进行聚焦微波辐照可有效且完全区域选择性地生成芳族CC和CN键。该方法简单，快速，通用且廉价，并且可以在不使用干燥溶剂的情况下进行。大多数合成的化合物都是新化合物，在许多情况下，仅需过滤即可进行后处理。此外，这是使用路易斯酸作为催化剂在π缺陷杂环底物上进行杂芳基化，乙烯基化和胺化反应的第一个例子。
• A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency
  作者：Abdellatif Fkyerat、Martine Demeunynck、Jean Francois Constant、Pierre Michon、Jean Lhomme

  DOI：10.1021/ja00075a011

  日期：1993.11

  A series of tailor-made molecules, 1 and 4-7, have been prepared to recognize and cleave DNA at apurinic sites. These molecules incorporate in their structure different units designed for specific functions: (1) an intercalator for DNA binding, (2) a nucleic base for abasic site recognition, and (3) a linker endowed with both a binding function and a cleavage function (Scheme II). The constituent units were varied successively in the series of molecules to get insight into their mode of action and prepare more active compounds. H-1 NMR spectroscopy reveals the absence of intramolecular ring-ring stacking interactions in water between the base and the intercalator in all molecules 1 and 4-7. All bind to calf thymus DNA with binding constants ranging from 10(4) to 10(6) M-1. Their nuclease activity was estimated by measuring their ability to induce single strand breaks in depurinated pBR 322 plasmid DNA. The most efficient molecule, 5, exhibits high recognition selectivity and cleavage efficiency: at nanomolar concentrations, 5 recognizes and cleaves the abasic lesion present in a DNA molecule containing an average of 1.8 apurinic sites in its 4 362 base pairs sequence. Molecule 5 exhibits higher cleaving efficiency than the reported tripeptide Lys-Trp-Lys: 10(-8) M concentrations of the former (5) lead to cleavage ratios comparable to those observed for the latter used as 10(-3) M concentration. This enzyme mimic 5 can be used advantageously as a substitute to the natural nuclease for in vitro cleavage of depurinated DNA.
• Ganapathi; Shah, Proceedings - Indian Academy of Sciences, Section A, 1951, # 34, p. 178,180
  作者：Ganapathi、Shah

  DOI：——

  日期：——
• The Role of Phenol in the Reaction of 4,7-Dichloroquinoline with Novol Diamine
  作者：Alexander R. Surrey、Royal A. Cutler

  DOI：10.1021/ja01150a060

  日期：1951.6