[(4S,5S,6R,9S,10R,12R)-5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxo-4-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl] (Z)-2-methylbut-2-enoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [(4S,5S,6R,9S,10R,12R)-5,6-dihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyl-15-oxo-4-tetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dienyl] (Z)-2-methylbut-2-enoate
• 化学式: C₂₅H₃₄O₆
• 分子量: 430.5
• InChiKey: VDJHFHXMUKFKET-YSQOVPITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
  申请人：Phyton Holdings, LLC

  公开号：US10172306B2

  公开（公告）日：2019-01-08

  The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.

  本发明涉及一种生产缩二烯醇、缩二烯醇酯和/或 Tiglian-3-one 衍生物的方法，该方法包括以下步骤：(a) 在营养培养基中以悬浮细胞培养法培养选自大戟科植物的植物细胞，其中细胞产生茵酚、一种或多种茵酚酯和/或一种或多种Tiglian-3-酮衍生物；以及 (b) 回收(a)中产生的茵酚、一种或多种茵酚酯和/或一种或多种Tiglian-3-酮衍生物。本发明还涉及一种植物悬浮细胞培养物，其中细胞来自选自大戟科的植物，植物细胞产生茵酚和/或一种或多种茵酚酯和/或一种或多种惕各-3-酮衍生物。
• METHOD OF PRODUCING INGENOL-3-ANGELATE
  申请人：LEO Laboratories Limited

  公开号：US20160280627A1

  公开（公告）日：2016-09-29

  The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
• PRODUCTION OF INGENOL, INGENOL ESTERS AND/OR TIGLIAN-3-ONE DERIVATIVES BY EUPHORBIACEAE PLANT CELL SUSPENSION CULTURES
  申请人：Phyton Holdings, LLC

  公开号：US20180042194A1

  公开（公告）日：2018-02-15

  The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives. The present invention further relates to a plant cell biomass comprising plant cells obtained from the suspension cell culture of the invention, and comprising Ingenol and/or one or more Ingenol esters and/or one or more Tiglian-3-one derivatives. Also, the present invention relates to cryopreserved cells of the plant suspension cell culture of the invention as well as to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives based on these cryopreserved cells.
• US9416083B2
  申请人：——

  公开号：US9416083B2

  公开（公告）日：2016-08-16
• US9676698B2
  申请人：——

  公开号：US9676698B2

  公开（公告）日：2017-06-13