(3Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-one | 305805-87-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-one
• 英文别名: (Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-one
• CAS: 305805-87-2
• 化学式: C₁₉H₁₈FIO₅
• 分子量: 472.252
• InChiKey: UKTODALGEMDIIK-KAMYIIQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (3Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-one 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 以94%的产率得到(3Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-ol
  参考文献：
  名称：

  Stereoselective Synthesis of (Z)-a-Phenoxymethylene-g-butyrolactone and Its Sulfur Analogues from 2-Propynyloxy- or 2-Propynylthiobenzene

  摘要：

  The preparations of (Z)-alpha -phenoxymethylene-gamma -butyrolactone, alpha -phenoxymethyl-gamma -butyrolactone, (Z)-alpha -phenylthiomethylene-gamma -butyrolactone, and alpha -phenylthiomethyl-gamma -butyrolactone derivatives from 2-propynyloxy-benzene and 2-propynylthiobenzene were described.

  DOI：

  10.3987/com-00-8964
• 作为产物：
  描述：

  1-氟-4-(2-丙炔-1-基氧基)苯 在 chromium(VI) oxide 、 三甲基氯硅烷 、 硫酸 、 乙基溴化镁 、 水 、 sodium iodide 作用下， 以 四氢呋喃 、 丙酮 、 乙腈 为溶剂， 生成 (3Z)-4-(4-fluorophenoxy)-3-iodo-1-(3,4,5-trimethoxyphenyl)but-3-en-1-one
  参考文献：
  名称：

  Stereoselective Synthesis of (Z)-a-Phenoxymethylene-g-butyrolactone and Its Sulfur Analogues from 2-Propynyloxy- or 2-Propynylthiobenzene

  摘要：

  The preparations of (Z)-alpha -phenoxymethylene-gamma -butyrolactone, alpha -phenoxymethyl-gamma -butyrolactone, (Z)-alpha -phenylthiomethylene-gamma -butyrolactone, and alpha -phenylthiomethyl-gamma -butyrolactone derivatives from 2-propynyloxy-benzene and 2-propynylthiobenzene were described.

  DOI：

  10.3987/com-00-8964

文献信息

• Stereoselective Synthesis of (Z)-a-Phenoxymethylene-g-butyrolactone and Its Sulfur Analogues from 2-Propynyloxy- or 2-Propynylthiobenzene
  作者：Fen-Tair Luo、Sheng-Li Ko、Lijun Liu、Hui Chen

  DOI：10.3987/com-00-8964

  日期：——

  The preparations of (Z)-alpha -phenoxymethylene-gamma -butyrolactone, alpha -phenoxymethyl-gamma -butyrolactone, (Z)-alpha -phenylthiomethylene-gamma -butyrolactone, and alpha -phenylthiomethyl-gamma -butyrolactone derivatives from 2-propynyloxy-benzene and 2-propynylthiobenzene were described.