7-phenyl-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one | 884495-80-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-phenyl-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one
• 英文别名: 7-phenyl-9,10,11,12-tetrahydro-7H-naphtho[1,2-b]quinolin-8-one
• CAS: 884495-80-1
• 化学式: C₂₃H₁₉NO
• 分子量: 325.41
• InChiKey: DOPMRNCGYPYSFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3-环己二酮 、 1-萘胺 、 苯甲醛 反应 0.05h， 以95.4%的产率得到7-phenyl-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one
  参考文献：
  名称：

  Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives

  摘要：

  Some new substituted tetrahydroacridin-8-ones and diverse derivatives were synthesized by uncatalysed multi-component reaction of dimedone or cyclohexan-1,3-dione, alpha-naphthylamine and various (o,p,m)-substituted benzaldehydes. The in vitro anti-microbial activities of the prepared compounds were evaluated against some bacteria and fungi strains. The results suggested that the products 2a-g and 4a-g exhibited good inhibitory effect against most of the tested organisms. Especially, 2f, 2g, 4f and 4g were shown to be most effective against Rhodotorula rubra and Aspergillus parasiticus and compounds 2a, 2c, 2g, 4f and 4g proved to be effective with MIC values in the range of 3.9-7.8 mu g/ml. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.07.004

文献信息

• Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives
  作者：Vetrivel Nadaraj、Senniappan Thamarai Selvi、Sellappan Mohan

  DOI：10.1016/j.ejmech.2008.07.004

  日期：2009.3

  Some new substituted tetrahydroacridin-8-ones and diverse derivatives were synthesized by uncatalysed multi-component reaction of dimedone or cyclohexan-1,3-dione, alpha-naphthylamine and various (o,p,m)-substituted benzaldehydes. The in vitro anti-microbial activities of the prepared compounds were evaluated against some bacteria and fungi strains. The results suggested that the products 2a-g and 4a-g exhibited good inhibitory effect against most of the tested organisms. Especially, 2f, 2g, 4f and 4g were shown to be most effective against Rhodotorula rubra and Aspergillus parasiticus and compounds 2a, 2c, 2g, 4f and 4g proved to be effective with MIC values in the range of 3.9-7.8 mu g/ml. (C) 2008 Elsevier Masson SAS. All rights reserved.