N-(2-aminoethyl)-2-oxo-1,2-dihydro-quinoline-3-carboxamide | 1352059-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-aminoethyl)-2-oxo-1,2-dihydro-quinoline-3-carboxamide
• 英文别名: N-(2-aminoethyl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide；N-(2-aminoethyl)-2-oxo-1H-quinoline-3-carboxamide
• CAS: 1352059-09-6
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: LUCIUQZPZMYKNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯甲醛 在 氯化亚砜 作用下， 以 水 、 丙酮 为溶剂， 反应 9.0h， 生成 N-(2-aminoethyl)-2-oxo-1,2-dihydro-quinoline-3-carboxamide
  参考文献：
  名称：

  Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APCMin/+ mice

  摘要：

  A selective KGFR tyrosine kinase inhibitor, N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide, was synthesized and its possible inhibitory effects on the development of colon polyps and colorectal tumors was examined in APC(Min/+) mice, a mouse model of human intestinal familial adenomatous polyposis. The present study shows for the first time that a dietary administration of a selective KGFR tyrosine kinase inhibitor lacks the overt-toxicities and significantly reduced the growth of small intestinal polyps in both male and female APC(Min/+) mice. This inhibition of polyp growth appears to occur at a greater extent in female mice. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.042

文献信息

• Synthesis and in vivo evaluation of N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide for inhibition of intestinal tumorigenesis in APCMin/+ mice
  作者：Gopal Pathuri、Qian Li、Altaf Mohammed、Hariprasad Gali、J. Thomas Pento、Chinthalapally V. Rao

  DOI：10.1016/j.bmcl.2014.01.042

  日期：2014.3

  A selective KGFR tyrosine kinase inhibitor, N-ethylamino-2-oxo-1,2-dihydro-quinoline-3-carboxamide, was synthesized and its possible inhibitory effects on the development of colon polyps and colorectal tumors was examined in APC(Min/+) mice, a mouse model of human intestinal familial adenomatous polyposis. The present study shows for the first time that a dietary administration of a selective KGFR tyrosine kinase inhibitor lacks the overt-toxicities and significantly reduced the growth of small intestinal polyps in both male and female APC(Min/+) mice. This inhibition of polyp growth appears to occur at a greater extent in female mice. (C) 2014 Elsevier Ltd. All rights reserved.