8-[2-(2-甲氧基乙氧基)乙氧基]辛-1-烯 | 102421-53-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 8-[2-(2-甲氧基乙氧基)乙氧基]辛-1-烯
• 英文名称: 8-<2-(2-methoxyethoxy)ethoxy>-1-octene
• 英文别名: 8-[2-(2-Methoxyethoxy)ethoxy]-1-octene；8-[2-(2-Methoxyethoxy)ethoxy]oct-1-ene
• CAS: 102421-53-4
• 化学式: C₁₃H₂₆O₃
• 分子量: 230.348
• InChiKey: XPBXHELXCOPYQG-UHFFFAOYSA-N

物化性质

• 沸点：
  80-90 °C(Press: 0.2 Torr)
• 密度：
  0.895±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-[2-(2-甲氧基乙氧基)乙氧基]辛-1-烯 在 吡啶 、 sodium hydroxide 、 2-甲基-2-丁烯 、 硼烷 、 双氧水 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.75h， 生成 20-[(4-methoxyphenyl)diphenylmethoxy]-2,5,8,17-tetraoxaeicosan-19-ol
  参考文献：
  名称：

  Analogs of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain

  摘要：

  Racemic analogues of platelet activating factor (PAF) in which the alkoxy chain (R = -O(CH2)15CH3) has been replaced with a chain containing multiple ether linkages near the end (17, R = -O(CH2)8O(CH2)2O(CH2)2OCH3) or at the beginning (18, R = -O(CH2)2O(CH2)2O(CH2)9CH3) of the chain have been prepared. Both compounds exhibit reduced hypotensive and platelet aggregation responses compared to racemic C16-PAF (1a). This reduction in the biological activities is more apparent when the new oxygen atoms are located near the end of the chain. This substitution of additional oxygen atoms into the alkoxy chain does not result in any dramatic gains in selectivity of the biological responses.

  DOI：

  10.1021/jm00157a038
• 作为产物：
  描述：

  二乙二醇单甲醚 、 8-溴-1-辛烯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以80%的产率得到8-[2-(2-甲氧基乙氧基)乙氧基]辛-1-烯
  参考文献：
  名称：

  Analogs of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain

  摘要：

  Racemic analogues of platelet activating factor (PAF) in which the alkoxy chain (R = -O(CH2)15CH3) has been replaced with a chain containing multiple ether linkages near the end (17, R = -O(CH2)8O(CH2)2O(CH2)2OCH3) or at the beginning (18, R = -O(CH2)2O(CH2)2O(CH2)9CH3) of the chain have been prepared. Both compounds exhibit reduced hypotensive and platelet aggregation responses compared to racemic C16-PAF (1a). This reduction in the biological activities is more apparent when the new oxygen atoms are located near the end of the chain. This substitution of additional oxygen atoms into the alkoxy chain does not result in any dramatic gains in selectivity of the biological responses.

  DOI：

  10.1021/jm00157a038

文献信息

• WISSNER, ALLAN
  作者：WISSNER, ALLAN

  DOI：——

  日期：——
• US4703130A
  申请人：——

  公开号：US4703130A

  公开（公告）日：1987-10-27
• US4939127A
  申请人：——

  公开号：US4939127A

  公开（公告）日：1990-07-03
• Analogs of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain
  作者：A. Wissner、C. A. Kohler、B. M. Goldstein

  DOI：10.1021/jm00157a038

  日期：1986.7

  Racemic analogues of platelet activating factor (PAF) in which the alkoxy chain (R = -O(CH2)15CH3) has been replaced with a chain containing multiple ether linkages near the end (17, R = -O(CH2)8O(CH2)2O(CH2)2OCH3) or at the beginning (18, R = -O(CH2)2O(CH2)2O(CH2)9CH3) of the chain have been prepared. Both compounds exhibit reduced hypotensive and platelet aggregation responses compared to racemic C16-PAF (1a). This reduction in the biological activities is more apparent when the new oxygen atoms are located near the end of the chain. This substitution of additional oxygen atoms into the alkoxy chain does not result in any dramatic gains in selectivity of the biological responses.