8-乙氧基喹啉-5-磺酸钠水合物 | 7246-07-3

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 8-乙氧基喹啉-5-磺酸钠水合物
• CAS: 7246-07-3
• 化学式: C11H11NNaO4S
• 分子量: 276.27
• InChiKey: RCVZWTQZOWXWQX-UHFFFAOYSA-N

物化性质

• 熔点：
  >280°C
• 稳定性/保质期：
  遵照规格使用和储存则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  84.9
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2933499090

文献信息

• Regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
  申请人：ALONSO Jorge

  公开号：US20100216988A1

  公开（公告）日：2010-08-26

  The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

  本发明涉及一种用于选择性合成式I化合物的过程，其中R1; R2; R3; R4; J1; J2; J3; J4和G具有声明中所示的含义。本发明提供了一种直接金属，例如钯或铜，催化的、选择性区域的过程，从2-卤代硝基芳烃和N-取代酰胺开始，合成广泛的非对称、多功能的N-取代苯并咪唑或氮杂苯并咪唑式I化合物。
• Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
  申请人：ALONSO Jorge

  公开号：US20100261909A1

  公开（公告）日：2010-10-14

  The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

  本发明涉及一种配合物I的区域选择性合成方法，其中R0; R1; R2; R3; R4; R5; A1; A2; A3; A4，Q和J具有声明中指示的含义。本发明提供了一种直接铜催化的区域选择性方法，可从2-卤代硝基芳烃和N-取代酰胺出发，合成广泛的非对称、多功能N-取代苯并咪唑或氮杂苯并咪唑配合物I。
• Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
  申请人：The Scripps Research Institute

  公开号：US10660899B2

  公开（公告）日：2020-05-26

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

  本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞向成熟髓鞘细胞命运分化的方法。本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者增加髓鞘化的方法。本发明还提供了使用神经递质受体调节剂治疗脱髓鞘疾病的方法。
• A REGIOSELECTIVE COPPER CATALYZED SYNTHESIS OF BENZIMIDAZOLES AND AZABENZIMIDAZOLES
  申请人：Sanofi-Aventis

  公开号：EP2173721A1

  公开（公告）日：2010-04-14
• A REGIOSELECTIVE METAL CATALYZED SYNTHESIS OF ANNELATED BENZIMIDAZOLES AND AZABENZIMIDAZOLES
  申请人：Sanofi-Aventis

  公开号：EP2173747A1

  公开（公告）日：2010-04-14