9H-9-flourenylmethyl-19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate | 913734-89-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-9-flourenylmethyl-19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate
• 英文别名: 9H-9-fluorenylmethyl 19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate；9H-fluoren-9-ylmethyl 19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate
• CAS: 913734-89-1
• 化学式: C₃₁H₃₉N₃O₈
• 分子量: 581.666
• InChiKey: DCUWGWFYQJYGSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  42
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  107
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  9H-9-flourenylmethyl-19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate 在 哌啶 、 N,N-二异丙基乙二胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.5h， 生成 21-(16-bromohexadecanoyl)-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-19,23-dione
  参考文献：
  名称：

  Surface-Based Lithium Ion Sensor:  An Electrode Derivatized with a Self-Assembled Monolayer

  摘要：

  自组装单层（SAMs）21-(16-巯基十六烷酰)-4,7,13,16-四氧-1,10,21-三氮双环[8.8.5]三十烷-19,23-二酮已在金表面制备。通过静滴接触角、椭偏法、浅角傅里叶变换红外光谱及电化学技术对SAM进行了表征。利用循环伏安法和阻抗光谱研究了该SAM的阳离子识别特性。该膜对溶液中的锂离子（Li+）相对于钾离子（K+）和钠离子（Na+）显示出适度选择性，选择性值计算为log KLi+,Na+ ∼ -1.30和log KLi+,K+ ∼ -0.92。根据我们的知识，这是首次展示使用自组装单层技术制造的锂传感器。

  DOI：

  10.1021/ac0603429
• 作为产物：
  描述：

  Fmoc-亚氨基二乙酸 在 氯化亚砜 、 N,N-二异丙基乙二胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.5h， 生成 9H-9-flourenylmethyl-19,23-dioxo-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-21-carboxylate
  参考文献：
  名称：

  Surface-Based Lithium Ion Sensor:  An Electrode Derivatized with a Self-Assembled Monolayer

  摘要：

  自组装单层（SAMs）21-(16-巯基十六烷酰)-4,7,13,16-四氧-1,10,21-三氮双环[8.8.5]三十烷-19,23-二酮已在金表面制备。通过静滴接触角、椭偏法、浅角傅里叶变换红外光谱及电化学技术对SAM进行了表征。利用循环伏安法和阻抗光谱研究了该SAM的阳离子识别特性。该膜对溶液中的锂离子（Li+）相对于钾离子（K+）和钠离子（Na+）显示出适度选择性，选择性值计算为log KLi+,Na+ ∼ -1.30和log KLi+,K+ ∼ -0.92。根据我们的知识，这是首次展示使用自组装单层技术制造的锂传感器。

  DOI：

  10.1021/ac0603429

文献信息

• Multi-transduction mechanism based microfluidic analyte sensors
  申请人：McGimpsey Grant W.

  公开号：US20070042450A1

  公开（公告）日：2007-02-22

  In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of analyte detection, utilize two transduction mechanisms from the same molecule to determine analyte presence, analyte concentration, or both. An analyte sensing molecule is used that can provide both an optical signal and electrochemical signal when an analyte is recognized by an analyte binding portion of the sensing molecule.

  提供了一种微流控和/或纳米流控传感器，可在多个方面提供有关其对样品中分析物存在性、样品中分析物浓度或两者的测量可靠性的指示。所提供的传感器、微流控装置和分析物检测方法利用同一分子的两种传导机制来确定分析物存在性、分析物浓度或两者。使用一种分析物感测分子，当分析物被感测分子的分析物结合部分识别时，可以同时提供光学信号和电化学信号。
• A Highly Selective Bicyclic Fluoroionophore for the Detection of Lithium Ions†
  作者：Nantanit Wanichecheva、John S. Benco、Christopher R. Lambert、W. Grant McGimpsey

  DOI：10.1562/2005-07-08-ra-606

  日期：——

  The macrobicyclic molecule, 21-(9-anthrylmethyl)-4,17,13,16-tetraoxa-1,10,21-triazabicyclo [8.8.5]tricosane-19,23-dione, I, was designed, synthesized and characterized as a fluoroionophore for the selective, optical detection of lithium ions. Compound I is based on a bridged diazacrown structure, which provides a semirigid binding framework. Binding takes place by electrostatic interactions between the oxygen atoms of the crown and the cation and is transduced to fluorescence emission from an attached anthracene fluorophore. In a 75:25 dichloromethane/tetrahydrofuran solvent mixture, I acts as an intramolecular electron transfer "off-on" fluorescence switch, exhibiting a greater than 190-fold enhancement in fluorescence emission intensity in the presence of lithium ions. The relative selectivity of I for lithium ions over sodium, potassium and ammonium ions was found to be log K-Li+,K-Na+ similar to -3.36, log K-Li+,K-K+ similar to -1.77 and 109 K-Li+,K-NH4+ similar to -2.78.
• US7935309B2
  申请人：——

  公开号：US7935309B2

  公开（公告）日：2011-05-03
• Surface-Based Lithium Ion Sensor:  An Electrode Derivatized with a Self-Assembled Monolayer
  作者：Nantanit Wanichacheva、Ernesto R. Soto、Christopher R. Lambert、W. Grant McGimpsey

  DOI：10.1021/ac0603429

  日期：2006.10.1

  Self-assembled monolayers (SAMs) of 21-(16-mercaptohexadecan-1-oyl)-4,7,13,16-tetraoxa-1,10,21-triazabicyclo[8.8.5]tricosane-19,23-dione were prepared on gold. Characterization of the SAMs was carried out by sessile drop contact angle, ellipsometry, grazing angle FT-IR spectroscopy, and electrochemical techniques. The cation recognition properties of the SAM were studied by cyclic voltammetry and impedance spectroscopy. The films show moderate selectivity for detection of Li+ ions in solution over K+ and Na+, with selectivity values calculated to be log KLi+,Na+ ∼ −1.30 and log KLi+,K+ ∼ −0.92. To the best of our knowledge, this is the first demonstration of a lithium sensor fabricated using self-assembled monolayer technology.

  自组装单层（SAMs）21-(16-巯基十六烷酰)-4,7,13,16-四氧-1,10,21-三氮双环[8.8.5]三十烷-19,23-二酮已在金表面制备。通过静滴接触角、椭偏法、浅角傅里叶变换红外光谱及电化学技术对SAM进行了表征。利用循环伏安法和阻抗光谱研究了该SAM的阳离子识别特性。该膜对溶液中的锂离子（Li+）相对于钾离子（K+）和钠离子（Na+）显示出适度选择性，选择性值计算为log KLi+,Na+ ∼ -1.30和log KLi+,K+ ∼ -0.92。根据我们的知识，这是首次展示使用自组装单层技术制造的锂传感器。