2-({4-[(7-Ethyl-1H-indol-3-yl)methyl]piperidin-1-yl}methyl)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinoline | 1026495-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-({4-[(7-Ethyl-1H-indol-3-yl)methyl]piperidin-1-yl}methyl)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinoline
• 英文别名: 2-[[4-[(7-ethyl-1H-indol-3-yl)methyl]piperidin-1-yl]methyl]-8-methyl-2,3-dihydro-[1,4]dioxino[2,3-f]quinoline
• CAS: 1026495-87-3
• 化学式: C₂₉H₃₃N₃O₂
• 分子量: 455.6
• InChiKey: UDGPINFJORGLBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl 4-methylbenzenesulfonate 、 7-ethyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole 在 氮气 、 乙酸乙酯 、 碳酸氢钠 、 水 、 Brine 、 Sodium sulfate-III 、 silica gel 、 乙醚 作用下， 以 二甲基亚砜 为溶剂， 反应 6.0h， 以to give 0.16 g of the (S)-enantiomer of the title compound as a yellow solid, m.p. 85-90° C.的产率得到2-({4-[(7-Ethyl-1H-indol-3-yl)methyl]piperidin-1-yl}methyl)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinoline
  参考文献：
  名称：

  ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINOLINE

  摘要：

  公式为1的化合物对于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性抑郁症）、焦虑症、恐慌症、创伤后应激障碍、经前期症候群（也称为经前综合征）、注意力缺陷障碍（有和没有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、进食障碍如厌食症、贪食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病方面具有用途。

  公开号：

  US20020165245A1

文献信息

• Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
  申请人：Wyeth

  公开号：US06458802B1

  公开（公告）日：2002-10-01

  Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  该公式化合物对抑郁症（包括但不限于重性抑郁障碍、儿童抑郁症和心境低落）、焦虑、恐慌障碍、创伤后应激障碍、经前期失调性障碍（也称为经前综合症）、注意力缺陷障碍（伴有和不伴有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、厌食症、暴食症、潮红、可卡因和酒精成瘾、性功能障碍及相关疾病的治疗具有用处。
• [EN] ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINOLINE<br/>[FR] DERIVES AZAHETEROCYCLYLMETHYLE ANTIDEPRESSEURS DE 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINOLINE
  申请人：WYETH CORP

  公开号：WO2002072587A1

  公开（公告）日：2002-09-19

  Compounds of the formula (I): are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addition, sexual dysfunction and related illnesses.

  公式（I）的化合物对于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性低落情感）、焦虑、恐慌症、创伤后应激障碍、经前期失调性情感障碍（也称经前综合征）、注意力缺陷障碍（有或没有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、饮食失调（如厌食症、贪食症）、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病具有治疗作用。
• Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline
  申请人：Wyeth

  公开号：US20030045542A1

  公开（公告）日：2003-03-06

  Compounds of the formula: 1 are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  公式为1的化合物可用于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和心境恶劣障碍）、焦虑症、恐慌症、创伤后应激障碍、经前期不良情绪障碍（也称经前综合征）、注意力缺陷障碍（伴有或不伴有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、进食障碍如厌食症、贪食症、潮红、可卡因和酒精成瘾、性功能障碍及相关疾病的治疗。
• ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINOLINE
  申请人：Wyeth

  公开号：US20020165245A1

  公开（公告）日：2002-11-07

  Compounds of the formula: 1 are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  公式为1的化合物对于治疗抑郁症（包括但不限于重度抑郁障碍、儿童抑郁症和慢性抑郁症）、焦虑症、恐慌症、创伤后应激障碍、经前期症候群（也称为经前综合征）、注意力缺陷障碍（有和没有多动症）、强迫症、社交焦虑障碍、广泛性焦虑障碍、肥胖症、进食障碍如厌食症、贪食症、血管运动性潮红、可卡因和酒精成瘾、性功能障碍及相关疾病方面具有用途。
• ANTIDEPRESSANT AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO 2,3-F]QUINOLINE
  申请人：Wyeth

  公开号：EP1392697A1

  公开（公告）日：2004-03-03